Related Experiment Video
Updated: Dec 29, 2025

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
Published on: September 29, 2011
Further survival at age 100: Findings from the Oporto Centenarian study
Laetitia Teixeira1, Lia Araújo2, Constança Paúl1
1Institute of Biomedical Sciences Abel Salazar, University of Porto, Porto, Portugal; CINTESIS.ICBAS-UP, University of Porto, Porto, Portugal.
Background:
This paper aims to identify the health-related predictors of survival in centenarians.
Methods:
A population-based study conducted in North Portugal (PT100) followed 140 individuals from the age of 100+ years. A detailed questionnaire at baseline was completed including information on sociodemographic characteristics, physical health, functional, cognitive, and nutritional status and life-style. Survival of study participants was checked every six months over the period of December 2013 until June 2019.
Results:
In the univariate Cox proportional hazards model, longer survival was associated with the absence of acute disease, better functional status, absence of physical fatigue and better cognition. Multivariate analysis revealed that acute disease, functional status and physical fatigue remained significant.
Conclusions:
Acute disease, functional status and physical fatigue are predictors of survival in the PT100 centenarians.
More Related Videos
Related Concept Videos
Cancer Survival Analysis
The Effect of Aging on Tissues
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
Life Tables
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

