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Updated: Dec 29, 2025
10:46
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
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Multiple modality approach to assess adherence to medications across time in Multiple Sclerosis
Efrat Neter1, Anat Wolkowitz2, Lea Glass-Marmor2
1Ruppin Academic Center, Israel.
Multiple Sclerosis and Related Disorders
|February 1, 2020
Summary
Medication adherence in Relapsing Multiple Sclerosis (RMS) is dynamic and requires multiple assessment methods over time. Patient-reported outcomes (PROs) are valuable for monitoring adherence and supporting patient-centered care.
Area of Science:
- Neurology
- Pharmacology
- Patient-Reported Outcomes
Background:
- Medication adherence is crucial for managing chronic conditions like Relapsing Multiple Sclerosis (RMS).
- Current adherence assessments in persons with MS (PwMS) often rely on single measures, primarily electronic pharmacy records.
- This study addresses the challenge of accurately measuring adherence in PwMS over time.
Purpose of the Study:
- To evaluate medication adherence in persons with MS (PwMS) using multiple methods across different time points.
- To examine the consistency of adherence measures over time.
- To investigate the associations between various adherence assessment tools.
Main Methods:
- Prospective survey of 194 PwMS at baseline, 6, and 12 months.
- Retrospective collection of health records and medication claims.
- Adherence scoring based on medication possession ratio (MPR) and two patient-reported outcome (PRO) measures.
- Exploration of electronic monitoring devices for adherence assessment.
Main Results:
- Medication possession ratio (MPR) was found to underestimate adherence when compared to prescription changes.
- Associations between MPR and PROs, and across time, were moderate (Kappa 0.37-0.42).
- Electronic monitoring devices were not adopted by patients; adherence rates were 66% (Time 1) and 64.9% (Time 2), with 21.1% consistently nonadherent. Adherence did not differ significantly by disease-modifying therapy (DMT) type.
Conclusions:
- Medication adherence is a dynamic behavior in MS requiring repeated, multi-modal monitoring.
- Integrating patient-reported outcomes (PROs) into adherence monitoring supports participatory medicine and patient-centered MS care.
- Focusing on adherence in clinician-patient interactions is essential for long-term MS management.
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