Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The interaction between prazosin and clonidine.

P A van Zwieten, E Lam, P B Timmermans

    Clinical Science and Molecular Medicine. Supplement
    |December 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Introducing a Novel Course-Based Undergraduate Research Experience Using Duckweed as a Model System.

    Integrative organismal biology (Oxford, England)·2026
    Same author

    Single-cell reconstruction of follicular remodeling in the human adult ovary.

    Nature communications·2019
    Same author

    BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity.

    Epigenetics & chromatin·2019
    Same author

    Strategies for successful recruitment of young adults to healthy lifestyle programmes for the prevention of weight gain: a systematic review.

    Obesity reviews : an official journal of the International Association for the Study of Obesity·2015
    Same author

    Regulation of Human Adenovirus Replication by RNA Interference.

    Acta naturae·2015
    Same author

    Assessment, validation and deployment strategy of a two-barcode protocol for facile genotyping of duckweed species.

    Plant biology (Stuttgart, Germany)·2014
    Same journal

    Closing address: au revoir et à bientôt.

    Clinical science and molecular medicine. Supplement·1978
    Same journal

    Antihypertensive therapy in patients above age 60 years (Fourth Interim report of the European Working Party on High Blood pressure in Elderly: EWPHE).

    Clinical science and molecular medicine. Supplement·1978
    Same journal

    The role of prostaglandins in the pathogenesis of hypertension.

    Clinical science and molecular medicine. Supplement·1978
    Same journal

    Implications of prostacyclin generation for modulation of vascular tone.

    Clinical science and molecular medicine. Supplement·1978
    Same journal

    The effects of calcium and calcium-ionophores (X 537 A and A 23187) on renin release in the isolated perfused rat kidney.

    Clinical science and molecular medicine. Supplement·1978
    Same journal

    Hypoxanthine--guanine phosphoribosyltransferase activity in blood and skeletal muscles of normal and dystrophic mice.

    Clinical science and molecular medicine. Supplement·1978
    See all related articles

    Prazosin reduces clonidine's blood pressure-lowering effects, particularly when both drugs act centrally. This interaction suggests combining these antihypertensives may decrease clonidine's effectiveness.

    Area of Science:

    • Pharmacology
    • Cardiovascular Research

    Background:

    • Clonidine is a centrally acting antihypertensive agent.
    • Prazosin is an alpha-1 adrenergic receptor antagonist.

    Purpose of the Study:

    • To investigate the interaction between prazosin and clonidine in animal models.
    • To determine the impact of prazosin on clonidine's hypotensive effects.

    Main Methods:

    • Experiments were conducted on anesthetized rats, pithed rats, and anesthetized cats.
    • Drug interactions were assessed by observing cardiovascular responses to prazosin and clonidine administration.

    Main Results:

    • Prazosin antagonized clonidine-induced hypotension in rats, suggesting central alpha-adrenoreceptor interaction.

    Related Experiment Videos

  • Prazosin partially reversed clonidine's effect on tachycardia in pithed rats, indicating presynaptic activity.
  • Central administration of prazosin reduced clonidine's hypotensive effect in cats, confirming a central mechanism.

    • Conclusions:

    • Prazosin interferes with the central antihypertensive action of clonidine.
    • Combined use of clonidine and prazosin may reduce therapeutic efficacy and should be discouraged.