Related Experiment Video

Updated: Dec 29, 2025

A Soluble Tetrazolium-Based Reduction Assay to Evaluate the Effect of Antibodies on Candida tropicalis Biofilms
06:50

A Soluble Tetrazolium-Based Reduction Assay to Evaluate the Effect of Antibodies on Candida tropicalis Biofilms

Published on: September 16, 2022

3.5K

Different efficacies of common disinfection methods against candida auris and other candida species

Leiwen Fu1, Tingting Le2, Zhihua Liu3

  • 1Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China.

Journal of Infection and Public Health
|February 2, 2020
PubMed
Abstract

Insights

Effective disinfection against Candida auris involves specific protocols. Washing skin with soap, drying, and applying an ethanol-based gel eradicates C. auris, while UV-C and ozone require extended exposure times for optimal results.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Hospital Infection Control

Background:

  • Candida auris forms persistent colonies on surfaces and skin, posing a significant hospital infection risk.
  • Limited data exists on effective disinfection strategies for C. auris in healthcare settings and on patients.

Purpose of the Study:

  • To evaluate the efficacy of various disinfectants and methods against Candida auris.
  • To determine optimal disinfection protocols for C. auris on skin and environmental surfaces.

Main Methods:

  • Minimum inhibitory concentrations of disinfectants (including "84" disinfectant, IodineTincture, quaternary ammonium, and 75% ethanol) against Candida species were determined.
  • A pig skin model assessed hand hygiene product efficacy; UV-C and ozone disinfection effects on C. auris were also evaluated.

Main Results:

  • Complete eradication of C. auris on pig skin was achieved with 30s soap wash, drying, and 15s ethanol-based gel application.
  • UV-C efficacy against C. auris on bed sheets decreased significantly at 1m distance.
  • Ozone effectively eradicated C. auris on bed sheets at 300 mg/m³ for 40 min, though C. auris showed higher ozone resistance.

Conclusions:

  • Extended disinfection times for UV-C and ozone are recommended.
  • Emphasize skin disinfection using soap, drying, and ethanol-based gel for C. auris removal.
Keywords:
Candida aurisDisinfectionHand hygieneInfection controlOzoneUltraviolet-C

More Related Videos

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance08:45

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

Published on: December 28, 2017

14.1K
Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds08:54

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds

Published on: February 14, 2018

19.8K

Related Concept Videos

Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
852
Hand hygiene01:23

Hand hygiene

Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
5.4K
Chemical Agents for Microbial Control01:27

Chemical Agents for Microbial Control

Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
665
Physical Methods for Controlling Microbial Growth: Radiation and Filtration01:26

Physical Methods for Controlling Microbial Growth: Radiation and Filtration

Radiation and filtration are essential tools for microbial control, targeting microorganisms through distinct mechanisms. Radiation eliminates microbes by damaging their DNA, either killing them or inhibiting their growth. Based on wavelength, radiation is classified into two types: nonionizing and ionizing radiation.Non-ionizing radiation, such as UV radiation (200–400 nm), is absorbed by DNA, causing defects that effectively disinfect surfaces, air, and water, including safety cabinets.
923
Surface Membrane Barriers01:18

Surface Membrane Barriers

The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
2.5K
Cleaning, Sterilization, and Disinfection01:30

Cleaning, Sterilization, and Disinfection

Cleaning, disinfection, and sterilization are the methods that help to break the infection chain and prevent disease.
Cleaning
The cleaning process usually involves using water with detergents or enzymatic cleaner and removing foreign material from objects and surfaces, including organic material such as body fluids or inorganic material like soil. Cleaning is performed before high-level disinfection and sterilization because foreign materials on the cover of the devices interfere with process...
9.5K