Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diencephalon: Thalamus and Information Relay01:27

Diencephalon: Thalamus and Information Relay

3.5K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is  a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
3.5K
Propagation of Action Potentials01:23

Propagation of Action Potentials

8.5K
The propagation of an action potential refers to the process by which a nerve impulse, or "action potential," travels along a neuron.
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...
8.5K
The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

3.6K
A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Galectin-8 Modulates Membrane CD44v Localization and Tempers STAT3 Signaling in Gastric Metaplasia.

bioRxiv : the preprint server for biology·2026
Same author

Galectin-3 is Necessary for Selective Cathartocytosis, which Expedites the Development of Proliferative Gastric SPEM.

bioRxiv : the preprint server for biology·2026
Same author

Longitudinal Awake Mouse Brain Imaging Using Functional Ultrasound and Functional Ultrasound Localization Microscopy.

bioRxiv : the preprint server for biology·2026
Same author

Stress-Responsive Protein IFRD1 Protects Assembled Ribosomes via a Ribosome-Salvaging Mechanism.

bioRxiv : the preprint server for biology·2026
Same author

Multimerin1 and not Galectin-8 tempers WNT signaling to promote gastric chief cell differentiation.

Scientific reports·2026
Same author

Safety Signals Enable Single-Episode Active Avoidance paradigm and Expose Threat Generalization in Tuberous Sclerosis Complex.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Dec 29, 2025

Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks
11:18

Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks

Published on: March 2, 2015

10.7K

Signal Propagation via Open-Loop Intrathalamic Architectures: A Computational Model.

Jeffrey W Brown1, Aynaz Taheri2, Robert V Kenyon2

  • 1College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801.

Eneuro
|February 2, 2020
PubMed
Summary

Open-loop pathways within the thalamus, particularly involving the thalamic reticular nucleus (TRN), facilitate signal propagation across the cerebral cortex. Heterogeneous, open-loop thalamo-reticulo-thalamic (TC-TRN-TC) networks enhance oscillatory activity transmission.

Keywords:
computational modelcortical signalingintrathalamic signalingopen-looppropagationthalamic reticular nucleus

More Related Videos

Neural Activity Propagation in an Unfolded Hippocampal Preparation with a Penetrating Micro-electrode Array
09:48

Neural Activity Propagation in an Unfolded Hippocampal Preparation with a Penetrating Micro-electrode Array

Published on: March 27, 2015

8.7K
Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments
05:19

Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments

Published on: November 12, 2019

7.4K

Related Experiment Videos

Last Updated: Dec 29, 2025

Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks
11:18

Closed-loop Neuro-robotic Experiments to Test Computational Properties of Neuronal Networks

Published on: March 2, 2015

10.7K
Neural Activity Propagation in an Unfolded Hippocampal Preparation with a Penetrating Micro-electrode Array
09:48

Neural Activity Propagation in an Unfolded Hippocampal Preparation with a Penetrating Micro-electrode Array

Published on: March 27, 2015

8.7K
Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments
05:19

Using Neuron Spiking Activity to Trigger Closed-Loop Stimuli in Neurophysiological Experiments

Published on: November 12, 2019

7.4K

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • Signal propagation in the cerebral cortex is crucial for cognition.
  • The thalamus was traditionally viewed as having parallel inputs to the cortex without internal connections.

Purpose of the Study:

  • To investigate the role of "open-loop" intrathalamic pathways in signal propagation.
  • To evaluate the contribution of thalamo-reticulo-thalamic (TC-TRN-TC) synaptic configurations to cortical signal transmission and oscillation.

Main Methods:

  • Utilized a supercomputing platform to simulate thousands of thalamocortical network permutations.
  • Incorporated physiological data from multiple species (mice, rats, ferrets, cats).
  • Varied synaptic properties (class and individual synapses) to compare closed-loop and open-loop TC-TRN-TC configurations.

Main Results:

  • Strong open-loop TC-TRN-TC connectivity optimally supported signal propagation.
  • Intrareticular synapses were not primary drivers of propagation or oscillation.
  • Heterogeneous synaptic networks demonstrated more robust propagation of oscillation than homogeneous networks.

Conclusions:

  • Open-loop intrathalamic architectures, especially heterogeneous ones, complement direct intracortical connections.
  • These pathways play a significant role in facilitating signal propagation and oscillatory activity across the cortex.