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Parathyroid hormone receptor 1 (PTHR1) is a prognostic indicator in canine osteosarcoma
Awf A Al-Khan1,2, Judith S Nimmo3, Mourad Tayebi4
1RMIT University, School of Health and Biomedical Sciences, Bundoora, 3083, Australia.
Scientific Reports
|February 2, 2020
Summary
High expression of parathyroid hormone-related protein receptor 1 (PTHR1) in canine osteosarcoma (OS) correlates with shorter survival times. This finding suggests PTHR1 can serve as a prognostic indicator for canine OS patients.
Area of Science:
- Veterinary Oncology
- Molecular Biology
- Biopathology
Background:
- Osteosarcoma (OS) is the most common primary bone tumor in dogs and humans.
- Parathyroid hormone-related protein (PTHrP) and its receptor (PTHR1) are crucial for bone remodeling and implicated in human tumor progression.
- The prognostic significance of PTHR1 and PTHrP in canine OS remains to be fully elucidated.
Purpose of the Study:
- To investigate the expression of PTHR1 and PTHrP in canine OS tissues.
- To evaluate the prognostic value of PTHR1 and PTHrP expression in canine OS.
Main Methods:
- Immunohistochemical analysis of PTHR1 and PTHrP expression in 50 formalin-fixed, paraffin-embedded canine OS tissue samples.
- Correlation analysis between immunostaining intensity and patient survival time using Log Rank and Cox regression models.
Main Results:
- Both PTHR1 and PTHrP were detected in all canine OS samples.
- Higher PTHR1 immunostaining intensity was significantly associated with shorter survival times in dogs with OS (p=0.028 Log Rank; p=0.04 Cox regression).
- PTHrP immunostaining intensity did not show a significant correlation with survival time (p>0.05).
Conclusions:
- Increased PTHR1 expression in canine OS is linked to a poor prognosis.
- PTHR1 may serve as a valuable prognostic biomarker for canine osteosarcoma.
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