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Updated: Dec 29, 2025

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

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WDR74 modulates melanoma tumorigenesis and metastasis through the RPL5-MDM2-p53 pathway

Yumei Li1, Yu Zhou1, Bifei Li1

  • 1Cancer Metastasis Alert and Prevention Center, College of Chemistry, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, 350116, Fujian, China.

Oncogene
|February 2, 2020
PubMed

Insights

Researchers identified WD repeat-containing protein 74 (WDR74) as a key driver of melanoma progression and metastasis. This protein promotes cancer cell growth and survival, offering a potential new target for melanoma treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Proteomics

Background:

  • Melanoma metastasis mechanisms are not fully understood.
  • Identifying key molecules driving melanoma progression is crucial for developing effective treatments.

Purpose of the Study:

  • To identify novel molecular players involved in melanoma progression and metastasis.
  • To elucidate the role and mechanism of WD repeat-containing protein 74 (WDR74) in melanoma.

Main Methods:

  • Isobaric tag for relative and absolute quantitation (iTRAQ) proteomic screening.
  • Gain- and loss-of-function studies in vitro and in vivo.
  • Analysis of the RPL5-MDM2-p53 signaling pathway.

Main Results:

  • WD repeat-containing protein 74 (WDR74) was identified as a key factor in melanoma.
  • WDR74 promotes melanoma cell proliferation, apoptosis resistance, and aggressive behavior.
  • WDR74 regulates the RPL5-MDM2-p53 pathway, impacting p53 stability.

Conclusions:

  • WDR74 plays a significant oncogenic role in melanoma progression and metastasis.
  • WDR74's regulation of the RPL5-MDM2-p53 pathway is a novel finding.
  • WDR74 represents a potential therapeutic target for melanoma treatment.

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