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Protein Nutrition in Autism

Saravana Babu Chidambaram1,2, Abid Bhat3,4, Arehally Marappa Mahalakshmi3

  • 1Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, India. babupublications@gmail.com.

Advances in Neurobiology
|February 2, 2020
PubMed

Insights

Emerging research links mitochondrial dysfunction to autism. Dietary interventions, including supplements and antioxidants, show promise in managing autistic symptoms by supporting mitochondrial health and reducing oxidative stress.

Area of Science:

  • Neurodevelopmental Disorders
  • Mitochondrial Biology
  • Nutritional Neuroscience

Background:

  • Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder impacting communication and behavior.
  • Current ASD therapies primarily manage behavioral abnormalities, with the root cause remaining unclear.
  • Emerging evidence suggests a significant link between mitochondrial dysfunction and the pathophysiology of autism.

Purpose of the Study:

  • To explore the role of mitochondrial dysfunction in autism.
  • To evaluate the potential of dietary interventions and supplements in managing ASD symptoms.
  • To investigate how targeting mitochondrial pathways may improve quality of life for individuals with autism.

Main Methods:

  • Review of emerging studies on mitochondrial dysfunction in autism.
  • Analysis of the effects of dietary supplements promoting mitochondrial biogenesis and inhibiting oxidative stress.
  • Examination of antioxidant supplementation's impact on cognitive and behavioral symptoms.

Main Results:

  • Mitochondrial dysfunction is increasingly implicated in autism.
  • Dietary adjustments and specific supplements show potential in suppressing autistic symptoms.
  • Antioxidant supplementation may improve cognitive function and behavioral outcomes in autism.

Conclusions:

  • Dietary interventions represent a novel approach to managing autism.
  • Targeting mitochondrial pathways with supplements and antioxidants offers a promising therapeutic avenue.
  • Further clinical trials are needed to validate the efficacy of nutraceuticals for autism.

Keywords:
ASDAmino acidsAutismDietary therapyGluten-free, casein-free (GFCF) dietMalabsorptionMitochondrial dysfunctionNutritional imbalancePeptidesProtein maldigestion

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