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Annexin A1: A double-edged sword as novel cancer biomarker
Zhuqiong Fu1, Shanshan Zhang1, Baiqi Wang2
1Cancer Research Institute of Hengyang Medical College, The University of South China, Hengyang, Hunan 421001, China.
Abstract:
The occurrence, development, infiltration and metastasis of tumors are very complex processes involving the participation of many factors, some of which play a key role. Annexin A1 (ANXA1) is known as an anti-inflammatory protein. However, it has now been recognized to have a broader role beyond the inflammation, including roles in cell proliferation, differentiation, apoptosis, invasion, angiogenesis and metastasis. This review is intended to outline the research surrounding the pathophysiological effects of ANXA1 in tumors and its potential as a therapeutic and diagnostic agent. These studies comprehensively explore the expression changes of ANXA1 in cancer and further explore its mechanism of action in tumors, which is of great clinical significance for the early diagnosis, treatment and prognostic evaluation of tumors.
Insights
Annexin A1 (ANXA1), initially known for anti-inflammatory roles, is now recognized for its significant involvement in tumor development, invasion, and metastasis. This review highlights ANXA1
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Annexin A1 (ANXA1) is traditionally recognized as an anti-inflammatory protein.
- Emerging research reveals ANXA1's multifaceted roles in cancer, extending beyond inflammation.
- These roles include regulating cell proliferation, differentiation, apoptosis, invasion, angiogenesis, and metastasis.
Purpose of the Study:
- To review the pathophysiological effects of ANXA1 in tumor development.
- To explore the potential of ANXA1 as a therapeutic and diagnostic agent in oncology.
- To consolidate current understanding of ANXA1's mechanisms in cancer progression.
Main Methods:
- Comprehensive literature review of studies on ANXA1 expression in various cancers.
- Analysis of research investigating ANXA1's molecular mechanisms in tumor biology.
- Evaluation of data on ANXA1's clinical significance in cancer diagnosis and prognosis.
Main Results:
- ANXA1 exhibits altered expression patterns across different tumor types.
- ANXA1 influences key cancer processes such as proliferation, invasion, and metastasis.
- Evidence suggests ANXA1's involvement in angiogenesis and apoptosis modulation within tumors.
Conclusions:
- ANXA1 plays a critical role in the complex processes of tumor occurrence, development, and metastasis.
- Understanding ANXA1's mechanisms offers significant potential for early cancer diagnosis and treatment strategies.
- ANXA1 represents a promising target for novel therapeutic interventions and prognostic biomarkers in oncology.
