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Updated: Dec 29, 2025

Characterizing Mutational Load and Clonal Composition of Human Blood
Published on: July 11, 2019
Clones assemble! The clonal complexity of blood during ontogeny and disease
Miguel Ganuza1, Trent Hall1, Esther A Obeng2
1Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN.
Abstract:
Hematopoietic stem and progenitor cells (HSPCs) govern the daily expansion and turnover of billions of specialized blood cells. Given their clinical utility, much effort has been made toward understanding the dynamics of hematopoietic production from this pool of stem cells. An understanding of hematopoietic stem cell clonal dynamics during blood ontogeny could yield important insights into hematopoietic regulation, especially during aging and repeated exposure to hematopoietic stress-insults that may predispose individuals to the development of hematopoietic disease. Here, we review the current state of research regarding the clonal complexity of the hematopoietic system during embryogenesis, adulthood, and hematologic disease.
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