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Knockout of farnesoid X receptor aggravates process of diabetic cardiomyopathy

Sujing Qiang1, Lingyun Tao2, Jie Zhou2

  • 1Department of Central Laboratory, Shanghai Tenth People's Hospital of Tongji University, Shanghai 200072, China.

Diabetes Research and Clinical Practice
|February 2, 2020
PubMed

Insights

FXR knockout worsens diabetic cardiomyopathy by increasing blood glucose and cardiac lipid accumulation. This study reveals FXR

Area of Science:

  • Cardiovascular Biology
  • Metabolic Diseases
  • Molecular Endocrinology

Background:

  • FXR (farnesoid X receptor) regulates glycolipid metabolism and inflammation.
  • FXR's role in cardiac tissue, particularly in diabetic cardiomyopathy, remains largely uncharacterized.

Purpose of the Study:

  • To investigate the functional role of FXR in diabetic cardiomyopathy.
  • To evaluate the impact of FXR knockout on cardiac function and pathology in a diabetic mouse model.

Main Methods:

  • Construction of a diabetic mouse model with FXR knockout (FXR-/-).
  • Assessment of cardiac function using echocardiography.
  • Histopathological analysis including HE, Masson staining, and α-SMA detection.
  • Biochemical analysis of blood glucose and cardiac triglyceride levels.

Main Results:

  • FXR knockout significantly elevated blood glucose levels in diabetic mice.
  • FXR deficiency aggravated cardiac dysfunction and pathological changes, including cardiac fibrosis.
  • FXR knockout exacerbated lipid accumulation in the cardiac tissue of diabetic mice.

Conclusions:

  • FXR plays a protective role in diabetic cardiomyopathy.
  • FXR knockout exacerbates hyperglycemia, cardiac fibrosis, and lipid accumulation.
  • FXR represents a potential therapeutic target for treating diabetic cardiomyopathy.
Keywords:
Cardiac fibrosisDiabetic cardiomyopathyFXRLipid accumulation

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