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Effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on ageing: Molecular mechanisms

Afsane Bahrami1, Simona Bo2, Tannaz Jamialahmadi3

  • 1Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.

Ageing Research Reviews
|February 2, 2020
PubMed

Insights

Statins, commonly used for lowering cholesterol, show potential in delaying human aging and inhibiting cellular senescence. This review explores their anti-aging mechanisms and impact on various diseases.

Area of Science:

  • Gerontology and Pharmacology
  • Cardiovascular Medicine

Background:

  • Human aging involves cellular senescence, organ dysfunction, and reduced repair capacity, increasing disease risk.
  • Statins (HMG-CoA reductase inhibitors) are primary lipid-lowering drugs reducing cardiovascular events.
  • Emerging evidence suggests statins possess pleiotropic effects beyond lipid reduction, including anti-aging properties.

Purpose of the Study:

  • To review the anti-aging mechanisms of statin drugs.
  • To investigate the effects of statins on cardiovascular and non-cardiovascular diseases related to aging.

Main Methods:

  • Literature review of recent studies on statins and aging.
  • Analysis of documented pleiotropic effects of statins.
  • Focus on research linking statins to senescence inhibition and age-related diseases.

Main Results:

  • Statins exhibit properties that may delay the aging process.
  • Evidence suggests statins can inhibit the onset of cellular senescence.
  • Pleiotropic effects of statins extend to potential benefits in cardiovascular and non-cardiovascular aging.

Conclusions:

  • Statins demonstrate promising anti-aging potential by targeting cellular senescence.
  • Further research into statins' role in mitigating age-related diseases is warranted.
  • Statins may offer a therapeutic strategy for managing aging and associated pathologies.
Keywords:
RhoASenescence-associated secretory phenotypeSirtuin-1Telomeraseklotho

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