Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

beta-Adrenoreceptor-blocking agents and lipid metabolism.

J D England, A S Hua, J Shaw

Clinical Science and Molecular Medicine. Supplement

|December 1, 1978

Summary

Essential hypertension was effectively controlled using chlorothiazide combined with various beta-blockers. These medications also caused minor increases in triglycerides and reduced glucagon levels.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

AAN guidelines: a benefit to the neurologist.

Neurology·2010

Same author

Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: drug, nutritional, and respiratory therapies (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology.

Neurology·2009

Same author

Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: multidisciplinary care, symptom management, and cognitive/behavioral impairment (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology.

Neurology·2009

Same author

Practice parameter: the evaluation of distal symmetric polyneuropathy: the role of laboratory and genetic testing (an evidence-based review). Report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation.

PM & R : the journal of injury, function, and rehabilitation·2009

Same author

Practice parameter: the evaluation of distal symmetric polyneuropathy: the role of autonomic testing, nerve biopsy, and skin biopsy (an evidence-based review). Report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation.

PM & R : the journal of injury, function, and rehabilitation·2009

Same author

Evaluation of distal symmetric polyneuropathy: the role of laboratory and genetic testing (an evidence-based review).

Muscle & nerve·2008

Area of Science:

Cardiology
Endocrinology
Pharmacology

Background:

Essential hypertension is a prevalent cardiovascular condition requiring effective management.
Beta-blockers are commonly prescribed for hypertension, but their metabolic effects warrant investigation.

Purpose of the Study:

To evaluate the efficacy of chlorothiazide in combination with different beta-blockers for essential hypertension.
To assess the impact of these combination therapies on plasma triglyceride and glucagon levels.

Main Methods:

Patients with essential hypertension received chlorothiazide twice daily.
Concurrently, patients were administered single daily doses of atenolol, metoprolol, pindolol, or propranolol.
Plasma triglyceride and fasting immuno-reactive glucagon concentrations were measured.

Main Results:

Combination therapy effectively controlled blood pressure in patients with essential hypertension.
All evaluated beta-adrenoreceptor-blocking drugs were associated with small, statistically significant increases in plasma triglyceride concentrations.
Fasting immuno-reactive glucagon concentrations were suppressed by each beta-blocker studied.

Conclusions:

Chlorothiazide combined with atenolol, metoprolol, pindolol, or propranolol offers effective blood pressure control for essential hypertension.
These beta-blockers may induce favorable or unfavorable metabolic changes, including altered lipid and glucose metabolism.

Related Experiment Videos