Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanical Ventilation I: Indication and Settings01:29

Mechanical Ventilation I: Indication and Settings

2.3K
Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
2.3K
Mechanical Ventilation III: Noninvasive Ventilation01:23

Mechanical Ventilation III: Noninvasive Ventilation

452
Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...
452
Mechanical Ventilation II: Invasive Ventilation01:23

Mechanical Ventilation II: Invasive Ventilation

550
Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
550
Ventilatory Modes01:14

Ventilatory Modes

1.1K
Mechanical ventilators are life-saving devices that support or replace spontaneous breathing. They deliver breaths to patients through varying methods known as ventilator modes. Understanding these modes is critical for healthcare providers managing patients with respiratory failure.
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
1.1K
Assessment of Ventilation I: Respiratory Rate01:20

Assessment of Ventilation I: Respiratory Rate

1.8K
Assessment of Ventilation
A Ventilation assessment is critical for monitoring a patient's health status. Respiration, one of the most accessible vital signs, provides insights into the function of numerous body systems and can indicate serious health issues, such as brainstem injuries from head trauma.
Critical Guidelines for Assessing Ventilation:
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tight Glycemic Control Can Be Achieved in Adult ICU Patients Safely: Results From a 5-Year Single-Center Observational Study Using the STAR Glycemic Control Framework.

Journal of diabetes science and technology·2026
Same author

Incorporating patient history into the insulin sensitivity prediction in intensive care by feedforward neural network models.

International journal of medical informatics·2026
Same author

Monitoring Airway Resistance for Obstructive Sleep Apnea Using a Leak-Based BiPAP System.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same author

A novel clinical data acquisition device: Towards real time cardiovascular modelling in the ICU.

HardwareX·2025
Same author

Evaluation of insulin sensitivity temporal prediction by using quantile regression combined with neural network model.

International journal of medical informatics·2025
Same author

Detection of spontaneous breathing during an apnea test in a patient with suspected brain death using electrical impedance tomography: a case report.

BMC pulmonary medicine·2024

Related Experiment Video

Updated: Dec 29, 2025

Ex Vivo Porcine Experimental Model for Studying and Teaching Lung Mechanics
12:09

Ex Vivo Porcine Experimental Model for Studying and Teaching Lung Mechanics

Published on: April 19, 2024

2.0K

Model-based PEEP titration versus standard practice in mechanical ventilation: a randomised controlled trial.

Kyeong Tae Kim1, Sophie Morton2, Sarah Howe2

  • 1Centre for Bioengineering, University of Canterbury, Christchurch, New Zealand. kyeong.kim@canterbury.ac.nz.

Trials
|February 3, 2020
PubMed
Summary

The CURE trial investigates using a model-based method to select positive end-expiratory pressure (PEEP) in acute respiratory distress syndrome (ARDS) patients on mechanical ventilation (MV). This patient-specific PEEP approach aims to improve clinical outcomes and guide critical care decisions.

Keywords:
ARDSMechanical ventilationPEEP titrationPulmonary mechanicsRCTrecruitment manoeuvre

More Related Videos

Monitoring Lung Function with Electrical Impedance Tomography in the Intensive Care Unit
05:56

Monitoring Lung Function with Electrical Impedance Tomography in the Intensive Care Unit

Published on: September 6, 2024

5.8K
Method of Isolated Ex Vivo Lung Perfusion in a Rat Model: Lessons Learned from Developing a Rat EVLP Program
08:59

Method of Isolated Ex Vivo Lung Perfusion in a Rat Model: Lessons Learned from Developing a Rat EVLP Program

Published on: February 25, 2015

28.4K

Related Experiment Videos

Last Updated: Dec 29, 2025

Ex Vivo Porcine Experimental Model for Studying and Teaching Lung Mechanics
12:09

Ex Vivo Porcine Experimental Model for Studying and Teaching Lung Mechanics

Published on: April 19, 2024

2.0K
Monitoring Lung Function with Electrical Impedance Tomography in the Intensive Care Unit
05:56

Monitoring Lung Function with Electrical Impedance Tomography in the Intensive Care Unit

Published on: September 6, 2024

5.8K
Method of Isolated Ex Vivo Lung Perfusion in a Rat Model: Lessons Learned from Developing a Rat EVLP Program
08:59

Method of Isolated Ex Vivo Lung Perfusion in a Rat Model: Lessons Learned from Developing a Rat EVLP Program

Published on: February 25, 2015

28.4K

Area of Science:

  • Critical Care Medicine
  • Respiratory Physiology
  • Clinical Trials

Background:

  • Positive end-expiratory pressure (PEEP) optimization is crucial for patients with acute respiratory distress syndrome (ARDS) on mechanical ventilation (MV).
  • Current PEEP selection methods may not account for individual patient respiratory system elastance variability.
  • The Clinical Utilisation of Respiratory Elastance (CURE) trial investigates a novel approach to PEEP selection.

Purpose of the Study:

  • To evaluate the clinical effectiveness of PEEP selected at minimal respiratory system elastance in ARDS patients.
  • To compare a model-based, objective PEEP selection method against standard practice.
  • To assess the impact of patient-specific PEEP on oxygenation and other clinical outcomes.

Main Methods:

  • A two-arm, randomized controlled trial (RCT) involving 320 ARDS patients requiring invasive MV.
  • Intervention group: PEEP selected using a model-based computerised method targeting minimal elastance.
  • Control group: PEEP selected per standard practice (SPV).
  • Primary outcome: Area Under the Curve (AUC) ratio of PaO2/FiO2 over time.

Main Results:

  • The study is designed to compare clinical outcomes between the two PEEP selection strategies.
  • Key secondary outcomes include duration of MV, ventilator-free days, ICU/hospital length of stay, and mortality.
  • Analysis will also assess oxygen saturation, respiratory mechanics, and use of rescue therapies.

Conclusions:

  • The CURE RCT is the first trial to compare clinical outcomes using an objective, model-based method for patient-specific PEEP selection in ARDS.
  • This approach quantifies and considers both inter-patient and intra-patient variability in respiratory elastance.
  • The trial aims to demonstrate the benefit of personalized PEEP and highlight the value of real-time monitoring and decision support in mechanical ventilation.