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MRI-guided adaptive radiotherapy for liver tumours: visualising the future
Jacob S Witt1, Stephen A Rosenberg2, Michael F Bassetti1
1Department of Human Oncology, University of Wisconsin-Madison, Madison, WI, USA.
The Lancet. Oncology
|February 3, 2020
Summary
MRI-guided radiotherapy offers precise, customizable radiation treatment for liver cancers by visualizing tumors and nearby tissues. This novel approach enhances the risk-benefit ratio, aiming for better tumor control and reduced toxicity.
Area of Science:
- Oncology
- Radiotherapy
- Medical Imaging
Background:
- MRI-guided radiotherapy is an evolving technology.
- It allows direct visualization of tumors and surrounding tissues.
- This enables precise radiation delivery, even for mobile targets.
Purpose of the Study:
- To review the current and future applications of MRI-guided radiotherapy for liver cancers.
- To highlight its potential to improve the risk-benefit ratio of treatment.
- To discuss its role in achieving durable local control of liver tumors.
Main Methods:
- Direct visualization of tumors and healthy tissues using MRI.
- Customization of individual treatment plans to adapt to changing anatomy.
- Application in both primary and metastatic liver cancers.
Main Results:
- Enhanced accuracy in radiation delivery to mobile targets.
- Potential reduction in radiation-related toxicities.
- Increased radiation dose delivery to the tumor.
- Opportunity for durable local control of liver tumors.
Conclusions:
- MRI-guided radiotherapy is a valuable tool for radiation oncologists treating liver cancer.
- It offers personalized treatment, improving outcomes and reducing side effects.
- Future advancements may expand patient eligibility and optimize treatment through AI and radiomics.
