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Raynaud's phenomenon.

Ariane L Herrick1, Fredrick M Wigley2

  • 1Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

Best Practice & Research. Clinical Rheumatology
|February 3, 2020
PubMed
Summary
This summary is machine-generated.

Raynaud

Keywords:
AutoantibodiesCapillaroscopyConnective tissue diseasePathogenesisRaynaud's phenomenonSystemic sclerosisTreatment

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Area of Science:

  • Rheumatology
  • Vascular Medicine

Background:

  • Raynaud's phenomenon (RP) affects 5% of the population.
  • RP is an early symptom of connective tissue diseases (CTD), particularly systemic sclerosis (SSc).
  • RP associated with SSc presents treatment challenges.

Purpose of the Study:

  • To review recent advances in understanding RP pathogenesis.
  • To discuss prediction of underlying CTD in RP patients.
  • To cover RP severity assessment and treatment of CTD-related digital vasculopathy.

Main Methods:

  • Literature review focusing on RP pathogenesis.
  • Discussion of clinical scenarios for assessment and management.
  • Exploration of diagnostic and therapeutic advances.

Main Results:

  • Understanding RP pathophysiology is key to developing new therapies.
  • Predicting CTD and assessing RP severity are crucial for early diagnosis.
  • Latest treatments for CTD-related digital vasculopathy are reviewed.

Conclusions:

  • Early diagnosis of CTD through RP is vital.
  • Advances in understanding RP pathophysiology will drive new treatments.
  • Effective management of RP and associated vasculopathy requires integrated approaches.