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CTLA-4: From mechanism to autoimmune therapy

Arezoo Hosseini1, Tohid Gharibi1, Faroogh Marofi2

  • 1Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

International Immunopharmacology
|February 3, 2020
PubMed
Summary

Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is crucial for immune tolerance by inhibiting T cell responses. Understanding CTLA-4

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