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Paediatric invasive pneumococcal disease from two tertiary hospitals in Malaysia

R Sithra1, N Jeyaseelan2, B Rohaiza3

  • 1Universiti Putra Malaysia, Faculty of Medicine and Health Sciences, Department of Paediatrics, Serdang, Selangor, Malaysia. ijah@upm.edu.my.

The Medical Journal of Malaysia
|February 3, 2020
PubMed

Insights

Invasive pneumococcal disease (IPD) presentation and outcomes vary between Malaysian hospitals. Understanding socio-demographics and healthcare factors is crucial for managing this serious childhood illness.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Invasive pneumococcal disease (IPD) is a significant cause of mortality and morbidity in children under five.
  • Understanding variations in IPD presentation and clinical course is essential for effective public health strategies.

Purpose of the Study:

  • To compare the presentation and clinical outcomes of IPD in children across two tertiary hospitals in Malaysia.
  • To identify factors influencing the varied clinical course of IPD.

Main Methods:

  • A retrospective study was conducted on Streptococcus pneumoniae isolates from children under 14 years old hospitalized between 2012 and 2016.
  • IPD cases were identified from normally sterile body fluid sites.

Main Results:

  • Fifty-four patients were identified; 35 from HRPB and 19 from HS.
  • The most common presentations were septicaemia, pneumonia, and meningitis.
  • Higher non-susceptibility rates were observed in HS (62.5%) versus HRPB (37.5%), and mortality was higher in HRPB (26%) compared to HS (11%).

Conclusions:

  • IPD presentation and outcomes differ between hospital settings, even within urban areas.
  • Socio-demographic factors, healthcare availability, and primary care practices significantly impact the clinical course of IPD.
Abstract

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