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High-sensitivity Troponin I Predicts Galectin-3 in Chronic Kidney Disease Patients
Gek Cher Chan1, Peh Joo Ho2, Jialiang Li3
1Division of Nephrology, Department of Medicine, National University Hospital, Singapore, Singapore. gek_cher_chan@nuhs.edu.sg.
Insights
Plasma galectin-3 (pG3) is elevated in chronic kidney disease (CKD). High-sensitivity Troponin I (hsTnI) is a better predictor of pG3 than B-type natriuretic peptide (BNP) in Asian CKD patients.
Area of Science:
- Biomarkers and inflammation research
- Cardiovascular and renal disease research
Background:
- Plasma galectin-3 (pG3) plays a role in inflammation.
- Elevated levels of B-type natriuretic peptide (BNP), high-sensitivity Troponin I (hsTnI), and pG3 are observed in patients with chronic kidney disease (CKD).
- The relationship between pG3 and hsTnI/BNP in CKD requires further investigation.
Purpose of the Study:
- To investigate the associations between hsTnI, BNP, and pG3 in Asian patients with CKD.
- To compare the predictive value of hsTnI and BNP for pG3 levels in this population.
Main Methods:
- Analysis of prospectively collected plasma samples from 163 stable CKD patients and 105 healthy controls.
- Assay of plasma galectin-3 (pG3), B-type natriuretic peptide (BNP), and high-sensitivity Troponin I (hsTnI).
- Multiple linear regression models were utilized to identify predictors of pG3, with model comparison using Akaike Information Criterion (AIC).
Main Results:
- CKD patients exhibited higher median BMI, serum creatinine, pG3, BNP, and hsTnI compared to healthy controls.
- Univariate analysis indicated associations between pG3 and multiple clinical and biochemical variables, excluding weight, gender, and specific vascular disease diagnoses.
- A parsimonious model identified hsTnI, BMI, serum albumin, cystatin C, and estimated glomerular filtration rate (eGFR) as significant predictors of pG3.
Conclusions:
- Both BNP and hsTnI are associated with pG3 in Asian CKD patients.
- hsTnI demonstrates a stronger predictive capability for pG3 levels compared to BNP in this cohort.
Purpose:
Plasma galectin-3 (pG3) regulates inflammation. B-type natriuretic peptide (BNP), high-sensitivity Troponin I (hsTnI), and pG3 concentrations are elevated in chronic kidney disease (CKD) patients. The associations of pG3 with hsTnI/BNP are unclear. We explored the relationship of hsTnI and BNP with pG3 in Asian CKD patients and healthy controls.
Methods:
We retrieved prospectively collected frozen plasma samples from 163 stable CKD patients and 105 healthy controls. BNP, hsTnI and pG3 were assayed. pG3 was assessed for associations with age, gender, ethnicity, blood pressures; height, weight, body mass index (BMI), previously diagnosed CKD, diabetes, hypertension, coronary artery disease, estimated glomerular filtration rate (eGFR); C-reactive protein, beta-trace protein, 24 h urine protein, serum albumin, uric acid and cystatin C. We created two models predicting pG3 using multiple linear regression. Akaike Information Criterion (AIC) was used for comparison. Significance was taken at P < 0.05.
Results:
CKD versus healthy participants: mean BMI (28.2 vs. 24.9 kg/m2), median serum creatinine (159 vs. 69 µmol/L; 1.8 vs. 0.78 mg/dL), median eGFR (49 vs. 104 mL/min/1.73m2), median pG3 (29.4 vs. 15.4 ng/mL), median BNP (136 vs. 23 pg/mL), and median hsTnI (12.5 vs. 2.6 pg/mL). By univariate analysis, all variables are associated with pG3 except weight, gender and diagnosis of cerebrovascular or peripheral vascular diseases. A parsimonious model selected for hsTnI, BMI, serum albumin, cystatin C and eGFR (AIC = 77.6).
Conclusion:
BNP and hsTnI are associated with pG3 in Asian CKD patients. hsTnI is a better predictor of pG3.
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