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Updated: Dec 29, 2025

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
Published on: March 3, 2023
Foot ulcers and their association with diabetic Charcot foot complications
Nabilah Abdul Rahman1, Aishah Ahmad Fauzi2, Tze Yang Chung2
1MBBS (IIUM), MRehab Med (UM), Rehabilitation Physician, Ministry of Health, Rehabilitation Medicine, Hospital Sultanah Bahiyah, Alor Setar, Kedah, Malaysia.
Background And Objectives:
Diabetic Charcot foot (DCF) can cause gross structural deformities of the foot and ankle. The main objective of this study was to identify complications of DCF and its associated factors.
Method:
This is a retrospective cohort study. Data on medical background, previous DCF treatment and complications were obtained. Multiple logistic regression analysis was performed to measure factors related to various complications of DCF.
Results:
Ninety-eight patient records were retrieved. Of the 83 patients who were still alive, 75.9% (n = 63) had recurrent ulcers, 53.0% (n = 44) had undergone foot surgery and 45.8% (n = 38) had undergone amputation. Patients with a history of recurrent ulcers have the highest predilection to amputation (odds ratio: 8.5; 95% confidence interval: 1.8, 39.1).
Discussion:
In terms of DCF complications, foot ulcers are an independent predictor of recurrent foot ulcers, foot surgery and amputation. Regular foot assessment of patients with DCF to prevent ulcers is strongly recommended.
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