Related Experiment Video
Updated: Dec 29, 2025
06:37
An Immature Murine Model of Reversible Unilateral Ureteral Obstruction
Published on: April 4, 2025
681
Lower Urinary Tract Dysfunction and Pediatric Renal Transplant.
Kaan Gulleroglu1, Esra Baskin, Mahir Kirnap
1From the Department of Pediatric Nephrology, Başkent University, Ankara, Turkey.
Summary
Pediatric renal transplant is viable for children with lower urinary tract dysfunction. Careful pre-transplant evaluation and preparation ensure similar graft outcomes compared to those without lower urinary tract abnormalities.
Area of Science:
- Urology
- Pediatric Nephrology
- Transplantation
Background:
- Lower urinary tract abnormalities were historically contraindications for renal transplant.
- Advances in diagnosis and treatment now permit renal transplant in select pediatric cases with lower urinary tract dysfunction.
Purpose of the Study:
- To evaluate the clinical outcomes of pediatric renal transplant in patients with lower urinary tract dysfunction.
- To compare graft survival and rejection rates between pediatric renal transplant recipients with and without lower urinary tract dysfunction.
Main Methods:
- Retrospective analysis of 165 pediatric renal transplant patients.
- Comparison of patient demographics, causes of chronic renal failure, acute rejection episodes, and graft loss between groups with and without lower urinary tract dysfunction.
Main Results:
- Seventeen patients had lower urinary tract dysfunction; 148 did not.
- Patients with lower urinary tract dysfunction were younger at diagnosis.
- Graft loss rates and acute rejection episodes were similar between groups, with only one graft loss in the lower urinary tract dysfunction group.
Conclusions:
- Pediatric renal transplant recipients with lower urinary tract dysfunction demonstrate comparable graft outcomes to those without.
- Thorough pre-transplant evaluation and preparation of the lower urinary tract are crucial for successful pediatric renal transplantation.
Related Concept Videos
01:26Kidney Transplant II: Surgical Procedure
242
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
242
01:16Kidney Transplant III: Nursing Management
267
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
267
01:28Kidney Transplant I: Introduction
274
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
274
01:20Disorders of the Urinary System
1.0K
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
1.0K
01:21Nursing Assessment of the Genitourinary System I: Health History
318
The genitourinary system is critical to maintaining fluid balance, waste elimination, and reproductive function. Nurses play a vital role in assessing this system, beginning with a thorough health history. This process involves gathering patient information, identifying risk factors, and recognizing symptoms of genitourinary disorders. Early detection is vital for timely interventions and management.1. Gathering Patient InformationA complete health history includes the patient’s personal,...
318
01:26Pharmacokinetics in Pediatric Patients: Drug Excretion
160
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
160