The Role of Electroconvulsive Therapy in the Treatment of Severe Bipolar Mixed State
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Updated: Dec 29, 2025

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
Published on: August 15, 2017
Giulio Perugi1, Pierpaolo Medda2, Margherita Barbuti2
1Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, Pisa 56100, Italy; Psychiatry Unit 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
Abstract:
Electroconvulsive therapy (ECT) results effective in two-thirds of the patients with severe and drug-resistant mixed states. The episode duration is the main predictor of nonresponse. This practice may increase the risk of mood destabilization and chronic complications and may decrease the chance of recovery in many patients. Compared with the burden of neurologic and metabolic side effects associated with long-term use of complex pharmacologic regimens, ECT should be considered a safe option with a very low incidence of severe adverse events and a long-term nondestabilizing effect.
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