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Exploring the molecular mechanism of azole resistance in Aspergillus fumigatus

P Chen1, J Liu1, M Zeng1

  • 1Department of Dermatology, Jinling Hospital, No. 305, Zhongshan East Rd., Nanjing 210002 Jiangsu Province, China.

Journal De Mycologie Medicale
|February 4, 2020
PubMed

Insights

Azole resistance in Aspergillus infections is a growing global health concern due to limited drug options. This review details molecular mechanisms and clinical relevance of azole resistance in Aspergillus fumigatus.

Area of Science:

  • Medical Mycology
  • Molecular Biology
  • Antimicrobial Resistance

Background:

  • Aspergillus infections pose a significant global health challenge.
  • Limited antifungal drugs and widespread azole resistance exacerbate this problem.
  • Emerging azole resistance necessitates understanding molecular mechanisms.

Purpose of the Study:

  • To review and summarize current research on molecular mechanisms of azole resistance in Aspergillus fumigatus.
  • To discuss the clinical relevance of identified resistance mechanisms.
  • To provide insights for developing effective prevention strategies.

Main Methods:

  • Literature review of recent clinical and laboratory studies.
  • Analysis of molecular biotechnology applications (e.g., next-generation sequencing, reverse genetics).
  • Synthesis of findings on cyp51-mediated and non-cyp51-mediated resistance.

Main Results:

  • Identification of various cyp51-mediated and non-cyp51-mediated azole resistance mechanisms.
  • Advancements in molecular techniques have enhanced understanding of these mechanisms.
  • Clinical relevance of bench work findings is being explored.

Conclusions:

  • A deeper understanding of azole resistance mechanisms in Aspergillus fumigatus is crucial.
  • Molecular insights can guide the development of novel prevention and treatment strategies.
  • Addressing azole resistance is vital for managing global Aspergillus infections.
Keywords:
Aspergillus fumigatusAzole resistanceNon-cyp51 mutationPathogenic fungicyp51 mutation

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