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Promising Effects of Benralizumab on Chronic Eosinophilic Pneumonia
Kohsuke Isomoto1,2, Tomohisa Baba1, Akimasa Sekine1
1Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Japan.
Abstract:
We herein report a case of refractory chronic eosinophilic pneumonia (CEP) complicated with uncontrolled bronchial asthma, in which remission was successfully induced with single dose of benralizumab, a monoclonal antibody against the alpha-chain of the interleukin-5 receptor. Resolution of the patient's symptoms and consolidation on chest X-ray were observed at 2 weeks and lasted for 8 weeks after the administration of benralizumab. Benralizumab would be a novel alternative choice of treatment for CEP patients who are at risk of potential toxicity due to long-term corticosteroid therapy.
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