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Related Experiment Video

Updated: Dec 29, 2025

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

DNA-Driven Nanoparticle Assemblies for Biosensing and Bioimaging.

Yuan Zhao^1,2, Lixia Shi³, Hua Kuang⁴

¹Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, 214122, Wuxi, Jiangsu, China. zhaoyuan@jiangnan.edu.cn.

Topics in Current Chemistry (Cham)

|February 4, 2020

Summary

This summary is machine-generated.

DNA nanotechnology enables precise nanoparticle assembly for tailored optical properties. This review covers DNA-driven nanoparticle configurations, optical characteristics, and applications in biosensing and bioimaging.

Keywords:

Assembly Bioimaging Biosensing DNA Nanoparticles Optical properties

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Last Updated: Dec 29, 2025

Folding and Characterization of a Bio-responsive Robot from DNA Origami

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Published on: December 3, 2015

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Published on: August 26, 2009

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Area of Science:

Nanotechnology
Biomaterials Science
Molecular Engineering

Background:

DNA molecules offer superior flexibility, affinity, and programmability for nanoparticle (NP) assembly.
Controlling DNA density, length, and sequences on NPs allows for rational design of NP assembly configurations.
Specific DNA recognition facilitates modifications to the spatial structures of NP assemblies, influencing tailorable optical signals.

Purpose of the Study:

To review the progress of DNA-driven NP assemblies.
To discuss tunable configurations based on DNA skeleton structural parameters.
To explore collective optical properties and engineered tailorable optical properties of these assemblies.

Main Methods:

Analysis of DNA-driven NP assembly fabrication techniques.
Investigation of structural parameters influencing NP assembly configurations.
Exploration of collective optical properties (chirality, fluorescence, SERS) of DNA-driven NP assemblies.

Main Results:

Tunable configurations of NP assemblies are achieved by manipulating DNA structural parameters.
Engineered tailorable optical properties, including chirality, fluorescence, and SERS, are demonstrated.
DNA-directed NP assemblies show potential for quantifying DNA, toxins, and heavy metal ions.

Conclusions:

DNA-driven NP assemblies offer significant potential for biosensing and bioimaging applications, including tumor markers and phototherapeutics.
Further development is needed to address challenges and realize practical applications in macroscopical materials and photonic devices.
This review provides comprehensive information beneficial for the fabrication and application of DNA-driven NP assemblies.