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A Study of the Serum Uric Acid Level as Prognostic Indicator in Acute Myocardial Infarction
Niraj Kumar1, Harender Kumar2, Vikas Kumar3
1DNB Resident.
Insights
Serum uric acid levels are associated with the severity of heart failure in patients with acute myocardial infarction. Higher uric acid levels correlate with increased Killip class, indicating worse left ventricular function and higher mortality risk.
Area of Science:
- Cardiology
- Biochemistry
Background:
- Coronary artery disease (CAD) is a leading cause of mortality.
- Serum uric acid may serve as a prognostic marker for mortality in acute myocardial infarction (AMI).
Purpose of the Study:
- To investigate the association between serum uric acid levels and Killip classes.
- To determine the relationship between serum uric acid levels and ejection fraction in AMI patients.
Main Methods:
- An observational prospective study enrolled 100 AMI patients.
- Serum uric acid, Killip classification, and ejection fraction were assessed on days 0, 3, and 7.
- Standard investigations including ECG and 2D-Echocardiogram were performed.
Main Results:
- Serum uric acid levels significantly increased with higher Killip classes (I-IV) on all assessment days.
- A significant negative correlation was observed between serum uric acid levels and ejection fraction on days 0, 3, and 7.
- The majority of patients (68%) were over 50 years old.
Conclusions:
- Elevated serum uric acid levels are significantly associated with higher Killip classes in AMI patients.
- Higher serum uric acid levels indicate more severe left ventricular dysfunction and increased mortality risk.
- Serum uric acid is a potential biomarker for assessing prognosis in acute myocardial infarction.
Background:
Coronary artery disease (CAD) is the leading cause of mortality and morbidity in present days. Recent epidemiological and clinical evidences suggest that serum uric acid can be one of the useful markers in assessing the risk of mortality in acute myocardial infarction.
Objective:
To find out the association in serum uric acid level and Killip classes and ejection fraction.
Methodology:
It was an observational prospective study. 100 patients of acute myocardial infarction were enrolled and physical examination with special reference to Killip classification, ECG, 2D- Echocardiogram, Serum uric acid and all routine investigations were carried out on 0, 3rd and 7th day. Serum uric acid and Killip class and ejection fractions on day 0, day 3 and day 7 were compared.
Results:
In this present study majority of the patients were in the age group of >50 years (68%). There was statistically significant increase in uric acid levels with increasing Killip class on day 0, day 3 and day 7. Mean serum uric acid level was 4.4 mg/dl in Killip class I, 7.01 mg/dl in class II, 8.29 mg/dl in class III, and 9.87 mg/ dl in class IV on day 0; 4.46 mg/dl in Killip class I, 7.09 mg/dl in class II, 8.53 mg/ dl in class III, and 9.43 mg/dl in class IV on day 3; 4.72 mg/dl in Killip class I, 6.62 mg/dl in class II, on day 7. There was statistically significant negative correlation (p-value 0.0009, 0.001, 0.0326 at day 0, 3 & 7) between serum uric acid levels and ejection fraction at all the three occasions i.e. day 0, day 3 and day 7.
Conclusion:
The present study concludes that serum uric acid level have significant association with Killip class, left ventricular failure and mortality i.e. higher the serum uric acid, higher the Killip class, more severe left ventricular dysfunction and higher the mortality.The present study concludes that serum uric acid level have significant association with Killip class, left ventricular failure and mortality i.e. higher the serum uric acid, higher the Killip class, more severe left ventricular dysfunction and higher the mortality.
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