Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

EPS and iPS Cells in Disease Research

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Rescue of mitochondrial and neurite pathology in <i>SPG7</i> hereditary spastic paraplegia patient-derived cortical neurons.

Brain communications·2026

Same author

Reply to: "Mathematical Comments on Linking Neurofilament Light Chain Levels to Disease Severity in HSP Subtypes SPG11 and SPG15".

Movement disorders : official journal of the Movement Disorder Society·2026

Same author

TNF alpha unmasks enteric malate aspartate shuttle dysfunction bridging Parkinson disease and intestinal inflammation.

Nature communications·2026

Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025

Same author

Spontaneous activity in pain patient stem cell-derived sensory neurons arises from one functional subclass.

Pain·2025

Same author

Deciphering brain organoid heterogeneity by identifying key quality determinants.

Communications biology·2025

Search research articles

Related Experiment Video

Updated: Dec 29, 2025

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons

Published on: July 7, 2023

Modeling Cell-Cell Interactions in Parkinson's Disease Using Human Stem Cell-Based Models.

Katrin Simmnacher¹, Jonas Lanfer¹, Tania Rizo¹

¹Department of Stem Cell Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

Frontiers in Cellular Neuroscience

|February 4, 2020

Summary

This summary is machine-generated.

Human stem cell models offer new ways to study Parkinson's disease (PD) pathology. This review covers generating neurons and 3D models to understand PD mechanisms and phenotypes in vitro.

Keywords:

Parkinson’s disease disease modeling dopaminergic neuron glia iPSC inflammation neurodegeneration organoid

More Related Videos

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

Published on: October 3, 2012

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Published on: May 2, 2025

Related Experiment Videos

Last Updated: Dec 29, 2025

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons

Published on: July 7, 2023

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

Published on: October 3, 2012

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Published on: May 2, 2025

Area of Science:

Neuroscience
Stem Cell Biology
Pathology

Background:

Parkinson's disease (PD) is a prevalent movement disorder with rising incidence.
Traditional post-mortem brain analysis is being complemented by advanced stem cell technologies.
Patient-specific neurons and glial cells offer novel insights into PD pathology.

Purpose of the Study:

To review prerequisites for human disease modeling in Parkinson's disease.
To examine the generation of midbrain neurons and 3D organoid models.
To discuss cell-cell interactions and phenotypes in vitro models of PD.

Main Methods:

Review of stem cell technologies for PD modeling.
Analysis of patient-specific induced pluripotent stem cells (iPSCs).
Examination of 2D and 3D in vitro models, including organoids.

Main Results:

Stem cell models enable dissection of pathological mechanisms in PD.
Major disease phenotypes in genetic and sporadic PD models are identified.
iPSC-derived technologies are crucial for modeling cell-cell interactions.

Conclusions:

Human in vitro models, particularly iPSC-based, are vital for understanding PD.
These models facilitate the study of morphological and functional deficits.
Advanced modeling approaches enhance the study of cell interactions in PD pathogenesis.