Related Experiment Video
Updated: Dec 29, 2025
09:35
Constitutive and Inducible Systems for Genetic In Vivo Modification of Mouse Hepatocytes Using Hydrodynamic Tail Vein Injection
Published on: February 2, 2018
15.0K
Factor VIII: Perspectives on Immunogenicity and Tolerogenic Strategies
David W Scott1, Kathleen P Pratt1
1Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
Frontiers in Immunology
|February 4, 2020
Summary
Therapeutic treatment with Factor VIII (FVIII) can trigger an antibody response that blocks its function. This review explores factors causing FVIII immunogenicity and strategies to overcome it.
Area of Science:
- Immunology
- Hematology
- Pharmacology
Background:
- Hemophilia A treatment involves Factor VIII (FVIII) replacement therapy.
- FVIII inhibitors (antibodies) are a significant complication, hindering treatment efficacy.
- Understanding inhibitor development is crucial for improving patient outcomes.
Purpose of the Study:
- To review the factors contributing to FVIII immunogenicity.
- To discuss strategies for overcoming FVIII antibody responses.
- To provide insights into managing inhibitor development in hemophilia.
Main Methods:
- Literature review of studies on FVIII immunogenicity.
- Analysis of factors influencing antibody formation against FVIII.
- Synthesis of current and emerging strategies to mitigate FVIII inhibitor risk.
Main Results:
- Immunogenicity is influenced by FVIII product characteristics, patient genetics, and treatment protocols.
- Various strategies, including immune tolerance induction and modified FVIII products, are being explored.
- Early identification and management of risk factors are key.
Conclusions:
- FVIII immunogenicity remains a major challenge in hemophilia care.
- A multi-faceted approach considering product, patient, and treatment factors is necessary.
- Further research is needed to develop more effective methods to prevent or manage FVIII inhibitors.
Related Concept Videos
01:22Biopharmaceutical Factors Influencing Drug Product Design: Overview
160
Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though...
160
01:29Microorganisms in Medicine and Therapeutics
868
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
868
01:20Special Features of Adaptive Immunity
2.8K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
2.8K
01:21Factors Affecting Drug Response: Overview
2.8K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.8K
01:26Antigens Involved in Adaptive Immunity
1.2K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
1.2K
01:27Tumor Immunotherapy
1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K