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PROTECTIVE EFFECT OF NIGELLA SATIVA OIL ON MYOCARDIUM IN STREPTOZOTOCIN-INDUCED DIABETIC RATS.

E Altun1, E Avci2, T Yildirim2

  • 1Balikesir University, School of Medicine - Dept. of Pathology, Balikesir, Turkey.

Acta Endocrinologica (Bucharest, Romania : 2005)
|February 4, 2020
PubMed
Summary

Nigella sativa oil (NSO) protects the heart in diabetic rats. NSO reduced heart damage and apoptosis, suggesting a therapeutic benefit for diabetes-related cardiac issues.

Keywords:
Bcl-2Nigella sativa oilapoptosisdiabetes mellitusmyocardium

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Area of Science:

  • Cardiovascular Research
  • Pharmacology
  • Diabetology

Background:

  • Diabetes mellitus (DM) can lead to significant cardiac complications.
  • Streptozotocin-induced diabetes is a common model for studying diabetic cardiomyopathy.
  • Oxidative stress and apoptosis play crucial roles in diabetic heart disease.

Purpose of the Study:

  • To investigate the cardioprotective potential of Nigella sativa oil (NSO) in a rat model of diabetes.
  • To assess the impact of NSO on myocardial histopathology and apoptosis markers in diabetic rats.

Main Methods:

  • Diabetes was induced in Wistar albino rats using streptozotocin (45 mg/kg).
  • Rats were divided into control, DM, NSO, and DM+NSO groups.
  • NSO (400 mg/kg/day) was administered orally for 21 days.
  • Myocardial tissues were analyzed using histopathology and immunohistochemistry, focusing on Bcl-2 expression.

Main Results:

  • Diabetic rats (DM group) exhibited significantly increased myositis, hyaline degeneration, and Zenker's necrosis in myocardial tissue compared to controls.
  • Nigella sativa oil administration (DM+NSO group) attenuated these diabetic-induced myocardial injuries.
  • Bcl-2 expression, an anti-apoptotic marker, was significantly higher in the NSO-treated groups (control, NSO, DM+NSO) compared to the untreated DM group.

Conclusions:

  • Nigella sativa oil demonstrates a significant protective effect on the myocardium in streptozotocin-induced diabetic rats.
  • The cardioprotective mechanism of NSO likely involves the suppression of apoptotic pathways.
  • NSO may be a potential therapeutic agent for managing cardiac complications associated with diabetes.