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THE METABOLIC SYNDROME IN OUTPATIENTS WITH PSYCHOSIS: A COMPARATIVE STUDY BETWEEN LONG ACTING INJECTABLE OLANZAPINE
L Dehelean1, A M Romosan1, M M Manea2,3
1"Victor Babes"University of Medicine and Pharmacy, Dept. of Neuroscience, Timisoara, Romania.
Acta Endocrinologica (Bucharest, Romania : 2005)
|February 4, 2020
Summary
Metabolic syndrome (MS) is common in patients on long-acting injectable (LAI) antipsychotics. While MS presence is linked to psychosis duration, hypertension may stem from age, stress, or risperidone treatment.
Area of Science:
- Psychiatry
- Pharmacology
- Metabolic Disorders
Background:
- Antipsychotic medications are associated with metabolic complications in patients.
- Metabolic syndrome (MS) and its components pose significant health risks.
Purpose of the Study:
- To compare the prevalence of MS and its components in outpatients receiving long-acting injectable (LAI) olanzapine versus risperidone.
- To investigate the relationship between MS, its components, and treatment parameters in patients with psychosis.
Main Methods:
- A double-center study involving outpatients with psychosis treated with either LAI olanzapine or risperidone.
- Analysis included demographic data, psychiatric symptom severity, vital signs, anthropometric measurements, blood glucose, lipid profiles, and treatment duration.
Main Results:
- Metabolic syndrome (MS) was present in 58.4% of the 77 included patients with schizophrenia and schizoaffective disorder.
- Higher durations of psychosis and LAI treatment were associated with MS and abdominal obesity.
- Risperidone use was linked to increased rates of hypertension and larger abdominal circumference compared to olanzapine.
Conclusions:
- MS prevalence is associated with psychosis duration and LAI treatment length, with no significant difference between olanzapine and risperidone.
- Hypertension in this cohort may be attributed to patient age, psychosis-induced stress, or risperidone treatment.
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