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CONGENITAL NEPHROGENIC DIABETES INSIPIDUS IN A PRETERM INFANT: CASE PRESENTATION
N Leonard1,2, R Mohora1,2, D Cretoiu3,4
1"Alessandrescu-Rusescu" National Institute for Mother and Child Health - Neonatology - Bucharest, Romania.
Acta Endocrinologica (Bucharest, Romania : 2005)
|February 4, 2020
Summary
Congenital nephrogenic diabetes insipidus (NDI) is rare in newborns. Early diagnosis and multidisciplinary care in preterm infants can prevent long-term complications like renal issues and developmental delays.
Area of Science:
- Neonatology
- Pediatric Nephrology
- Endocrinology
Background:
- Congenital nephrogenic diabetes insipidus (NDI) is a rare but serious neonatal condition.
- Neonatal NDI presents diagnostic challenges due to immature kidney function and electrolyte fluctuations.
Observation:
- A very low birth weight preterm infant presented with persistent hypernatremia, hyperosmolarity, polyuria, and polydipsia.
- The infant exhibited persistently elevated presepsin levels, prompting further investigation into renal hypernatremia.
Findings:
- Diagnosis of congenital NDI was confirmed through laboratory tests, vasopressin levels, and family history.
- Early symptomatic treatment and multidisciplinary management led to positive infant development.
Implications:
- Early detection and intervention are crucial for preventing severe outcomes in neonatal NDI.
- Multidisciplinary care and frequent monitoring are essential for managing NDI and mitigating long-term complications.
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