Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hypothalamic-Pituitary Axis

Hypothalamic-Pituitary Axis

The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.

Psychoneuroimmunology: Diabetes and Cancer

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...

An Overview of the Endocrine System

An Overview of the Endocrine System

The endocrine system, a complex network of glands, orchestrates physiological balance within the body through the production and secretion of hormones. These hormones are chemical messengers in intercellular communication, acting as conduits between the secretory cells and distant target sites. They traverse the circulatory system by being released into the extracellular fluid, and their impact is specific to cells possessing receptors for a particular hormone.
The endocrine system collaborates...

Introduction to Stress and Lifestyle

Introduction to Stress and Lifestyle

Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...

Physiological Foundation of Stress

Physiological Foundation of Stress

Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

THYROID HORMONES AS A THIRD LINE OF AUGMENTATION MEDICATION IN TREATMENT-RESISTANT DEPRESSION.

Acta endocrinologica (Bucharest, Romania : 2005)·2020

Same author

THE NEUROENDOCRINOLOGICAL ASPECTS OF PREGNANCY AND POSTPARTUM DEPRESSION.

Acta endocrinologica (Bucharest, Romania : 2005)·2020

See all related articles

Search research articles

Related Experiment Video

Updated: Dec 29, 2025

Burn Injury-Induced Pain and Depression-Like Behavior in Mice

Burn Injury-Induced Pain and Depression-Like Behavior in Mice

Published on: September 29, 2021

NEUROENDOCRINE INSIGHTS INTO BURNOUT SYNDROME.

¹"Carol Davila" University of Medicine and Pharmacy - Neurosciences, Bucharest, Romania.

Acta Endocrinologica (Bucharest, Romania : 2005)

|February 4, 2020

Summary

Burnout research explores its link to physiological changes and job stress. Studies examine neuroendocrine indicators, revealing biphasic changes in the neuro-immuno-endocrine axis during illness adaptation.

Area of Science:

Medical Psychology
Endocrinology
Neuroimmunology

Background:

Ongoing debate exists regarding burnout classification: distinct illness, separate entity, or job-related reaction.
Burnout is often viewed as a form of depression, prompting research into its physiological correlates.
The neuro-immuno-endocrine axis plays a crucial role in the body's response to stress and illness.

Purpose of the Study:

To review recent studies on neuroendocrine indicators associated with burnout.
To explore the relationship between burnout, physiological changes, and job-related factors.
To understand the adaptive changes within the neuro-immuno-endocrine axis during critical illness phases.

Main Methods:

Literature review of recent studies on burnout and neuroendocrine function.

Keywords:

HPT axis burnout neuroendocrine system

More Related Videos

Mindfulness in Motion MIM: An Onsite Mindfulness Based Intervention MBI for Chronically High Stress Work Environments to Increase Resiliency and Work Engagement

Mindfulness in Motion MIM: An Onsite Mindfulness Based Intervention MBI for Chronically High Stress Work Environments to Increase Resiliency and Work Engagement

Published on: July 1, 2015

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model

Published on: April 12, 2024

Related Experiment Videos

Last Updated: Dec 29, 2025

Burn Injury-Induced Pain and Depression-Like Behavior in Mice

Burn Injury-Induced Pain and Depression-Like Behavior in Mice

Published on: September 29, 2021

Mindfulness in Motion MIM: An Onsite Mindfulness Based Intervention MBI for Chronically High Stress Work Environments to Increase Resiliency and Work Engagement

Mindfulness in Motion MIM: An Onsite Mindfulness Based Intervention MBI for Chronically High Stress Work Environments to Increase Resiliency and Work Engagement

Published on: July 1, 2015

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model

Published on: April 12, 2024

Analysis of research investigating correlations between job stress, physiological changes, and burnout.

Examination of studies focusing on the neuro-immuno-endocrine axis in acute and chronic illness.

Main Results:

Neuroendocrine indicators are increasingly implicated in the pathophysiology of burnout.
Biphasic changes in the neuro-immuno-endocrine axis are observed during acute and chronic illness phases.
These neuroendocrine shifts may represent adaptive responses to critical illness.

Conclusions:

Burnout research is increasingly focusing on neuroendocrine mechanisms.
The neuro-immuno-endocrine system exhibits dynamic changes in response to stress and illness, potentially linked to burnout.
Understanding these neuroendocrine adaptations is vital for a comprehensive view of burnout.