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Predictions of Hypoxic-Ischemic Encephalopathy by Umbilical Cord Blood Lactate in Newborns with Birth Asphyxia
Ton Nu Van Anh1, Tran Kiem Hao2, Nguyen Thi Diem Chi2
1Pediatric Department, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam.
Aim:
The aim of the study was to investigate the role of umbilical cord blood lactate as early predictors of hypoxic ischemic encephalopathy in newborns with perinatal asphyxia and to evaluate their sensitivity and specificity for the early identification of hypoxic ischemic encephalopathy infants.
Methods:
We performed a descriptive cross sectional study between April 2014 and April 2015 at Hue Central Hospital, Vietnam. 41 asphyxia newborns (Apgar score ≤ 7) were included in the study. Umbilical cord blood is sampled for lactate analysis.
Results:
Umbilical cord blood lactate levels were significantly higher among infants born with HIE (mean 8.72 ± 1.75, range 5.12 - 11.96) compared to that with asphyxic infants without HIE (mean 6.86 ± 1.33, range 4.74 - 10.30), p = 0.00. With the optimal cutoff point for umbilical cord blood lactate level of 8.12 mmol/l to susspected of HIE (area under the curve 0.799) had a sensitivity 73.7% (95% CI 48.8-90.9), specificity 86.4% (95% CI 65.1-97.1).
Conclusion:
Umbilical cord blood lactate could be used as early predictors in diagnosis of hypoxic ischemic encephalopathy in newborns with asphyxia.
