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Updated: Dec 29, 2025

Probiotic Studies in Neonatal Mice Using Gavage
Published on: January 27, 2019
A dose-finding study for a supplement containing Lactococcus lactis subsp. cremoris FC in healthy adults with mild
Yayoi Gotoh1, Fumio Nanba1, Nobuhiko Shioya2
1Fujicco Co., Ltd., 6-13-4 Minatojima-nakamachi, Chuo-ku, Kobe, Hyogo 650-8558, Japan.
Abstract:
A dose-escalation study was conducted to find the effective dose of Lactococcus lactis subsp. cremoris FC for improving defecation in healthy subjects. Twenty-seven subjects were recruited and consecutively ingested a placebo and two dose levels of L. cremoris FC (dose level 1, 1 × 107 cfu; dose level 2, 2 × 107 cfu) capsules daily for two weeks. Frequency of defecation (times/week) was significantly increased by dose level 2, and stool volume (units/week) was significantly increased by dose level 1. This dose-escalation study elucidated that intake of at least 1 × 107 cfu L. cremoris FC improves defecation.
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