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IGF2BP3 From Physiology to Cancer: Novel Discoveries, Unsolved Issues, and Future Perspectives

Caterina Mancarella1, Katia Scotlandi1

  • 1Laboratory of Experimental Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Frontiers in Cell and Developmental Biology
|February 4, 2020
PubMed

Insights

RNA-binding proteins (RBPs) regulate cellular homeostasis, but aberrant expression, like that of insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), drives cancer. Understanding IGF2BP3

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • RNA Biology

Background:

  • RNA-binding proteins (RBPs) are crucial regulators of RNA metabolism and cellular homeostasis.
  • Dysregulation of RBPs contributes to various pathologies, notably cancer.
  • Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) is implicated in tumorigenesis and cancer progression.

Purpose of the Study:

  • To review the molecular mechanisms of IGF2BP3's oncogenic functions.
  • To summarize the therapeutic potential of targeting IGF2BP3.
  • To identify unanswered questions critical for IGF2BP3-based diagnostics and therapeutics.

Main Methods:

  • Literature review focusing on molecular mechanisms.
  • Analysis of studies on IGF2BP3's role in cancer.
  • Synthesis of current knowledge on IGF2BP3's interactions and regulation.

Main Results:

  • IGF2BP3 exhibits significant oncogenic functions in tumorigenesis and progression.
  • Inhibition of IGF2BP3 shows therapeutic promise for cancer treatment.
  • Key unanswered questions remain regarding IGF2BP3 re-expression and target mRNA interactions.

Conclusions:

  • IGF2BP3 is a critical player in cancer development and progression.
  • Targeting IGF2BP3 offers a potential therapeutic strategy.
  • Further research is needed to understand IGF2BP3 regulation and function in cancer.
Keywords:
IGF2BP3RNA-binding proteinbiomarkercancerembryonic development

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