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Updated: Dec 29, 2025

Single Molecule Fluorescence Microscopy on Planar Supported Bilayers
Published on: October 31, 2015
Picosecond-resolution phase-sensitive imaging of transparent objects in a single shot
Taewoo Kim1, Jinyang Liang1, Liren Zhu1
1Caltech Optical Imaging Laboratory, Andrew and Peggy Cherng Department of Medical Engineering, California Institute of Technology, 1200 East California Boulevard, Mail Code 138-78, Pasadena, CA 91125, USA.
Abstract:
With the growing interest in the optical imaging of ultrafast phenomena in transparent objects, from shock wave to neuronal action potentials, high contrast imaging at high frame rates has become desirable. While phase sensitivity provides the contrast, the frame rates and sequence depths are highly limited by the detectors. Here, we present phase-sensitive compressed ultrafast photography (pCUP) for single-shot real-time ultrafast imaging of transparent objects by combining the contrast of dark-field imaging with the speed and the sequence depth of CUP. By imaging the optical Kerr effect and shock wave propagation, we demonstrate that pCUP can image light-speed phase signals in a single shot with up to 350 frames captured at up to 1 trillion frames per second. We expect pCUP to be broadly used for a vast range of fundamental and applied sciences.

