Deep Eutectic Solvent-Assisted Synthesis of Au Nanostars Supported on Graphene Oxide as an Efficient Substrate for...

The development of hybrid nanostructures of graphene oxide (GO) and metal nanoparticles (NPs) is of paramount interest for highly flexible surface-enhanced Raman scattering (SERS) substrate-based molecular sensing. In this work, we report a simple and eco-friendly synthesis strategy for the synthesis of a three-dimensional (3D) GO/gold nanostar (3D GO/Au NS) hybrid nanocomposite using deep eutectic solvent (DES) for SERS-based molecular sensing. The 3D GO/Au NS hybrid nanocomposite was obtained by a two-step synthetic process. In the first step, the GO nanosheets of thickness ∼1.25 nm were homogeneously dispersed in choline chloride/urea (molar ratio of 1:2)-derived DES, followed by functionalization of -NH groups using 3-aminopropyltriethoxysilane. Afterward, the presynthesized Au NSs of size ranging between 150-200 nm were then covalently attached on the -NH-functionalized GO nanosheets mediated by DES at 60 °C to obtain 3D GO/Au NS hybrid nanocomposites. Importantly, the SERS substrate fabricated using the 3D GO/Au NS hybrid nanocomposite exhibits highly enhanced SERS activity with an enhancement factor of 1.7 × 10⁵ and high sensitivity for the detection of crystal violet with a concentration up to 10^-11 M. The green synthetic approach presented here can be expected to be promising for the large-scale fabrication of GO-metal NP-based hybrid nanostructures for their potential applications in SERS-based sensing.