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Updated: Dec 29, 2025
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Periodontitis and cardiovascular diseases: Consensus report
Mariano Sanz1, Alvaro Marco Del Castillo2, Søren Jepsen3
1Department of Dental Clinical Specialties, ETEP Research Group, Faculty of Odontology, University Complutense of Madrid, Madrid, Spain.
Insights
Severe periodontitis is linked to cardiovascular disease (CVD), a leading cause of death in Europe. This review updates evidence on this association and provides clinical recommendations for managing patients with both conditions.
Area of Science:
- Periodontology
- Cardiology
- Public Health
Background:
- Cardiovascular disease (CVD) causes 45% of deaths in Europe, with ischaemic heart disease and stroke as primary drivers.
- Periodontitis, a prevalent chronic disease, affects 11.2% of the global population, with severe forms being the sixth most common human disease.
- Existing evidence suggests independent associations between severe periodontitis and non-communicable diseases (NCDs), particularly CVD.
Purpose of the Study:
- To update epidemiological evidence on the association between periodontitis and CVD.
- To review mechanistic links between periodontitis and CVD.
- To assess the impact of periodontal therapy on cardiovascular outcomes and patient management.
Main Methods:
- A joint workshop by the European Federation of Periodontology (EFP) and World Heart Federation (WHF) reviewed recent scientific literature.
- The review synthesized epidemiological data, mechanistic insights, and clinical trial findings.
- Consideration was given to risks associated with periodontal therapy in patients on antithrombotic medication.
Main Results:
- Significant associations between periodontitis and CVD are supported by updated epidemiological evidence.
- Mechanistic pathways linking periodontitis and CVD have been further elucidated.
- The impact of periodontal therapy on cardiovascular and surrogate outcomes has been evaluated.
Conclusions:
- Periodontal therapy can influence cardiovascular and surrogate outcomes.
- Recommendations are provided for dentists, physicians, and patients regarding the management of periodontitis and CVD.
- Potential risks and complications of periodontal therapy in patients on antithrombotic therapy are addressed.
Background:
In Europe cardiovascular disease (CVD) is responsible for 3.9 million deaths (45% of deaths), being ischaemic heart disease, stroke, hypertension (leading to heart failure) the major cause of these CVD related deaths. Periodontitis is also a chronic non-communicable disease (NCD) with a high prevalence, being severe periodontitis, affecting 11.2% of the world's population, the sixth most common human disease.
Material And Methods:
There is now a significant body of evidence to support independent associations between severe periodontitis and several NCDs, in particular CVD. In 2012 a joint workshop was held between the European Federation of Periodontology (EFP) and the American Academy of Periodontology to review the literature relating periodontitis and systemic diseases, including CVD. In the last five years important new scientific information has emerged providing important emerging evidence to support these associations RESULTS AND CONCLUSIONS: The present review reports the proceedings of the workshop jointly organised by the EFP and the World Heart Federation (WHF), which has updated the existing epidemiological evidence for significant associations between periodontitis and CVD, the mechanistic links and the impact of periodontal therapy on cardiovascular and surrogate outcomes. This review has also focused on the potential risk and complications of periodontal therapy in patients on anti thrombotic therapy and has made recommendations for dentists, physicians and for patients visiting both the dental and medical practices.
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