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Variation in Prehospital Protocols for Pediatric Seizure Within the United States
Sriram Ramgopal1, Kerry McCans2, Christian Martin-Gill3
1From the Division of Emergency Medicine, Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Chicago, IL.
Insights
Statewide prehospital protocols for pediatric seizures vary widely in medication choices and dosing. Further research is needed to optimize emergency medical services (EMS) management of pediatric seizures, including blood glucose monitoring and medication administration routes.
Area of Science:
- Emergency medicine
- Pediatric neurology
- Public health policy
Background:
- Prehospital management of pediatric seizures is critical for patient outcomes.
- Standardized protocols are essential for consistent emergency medical services (EMS) care.
- Existing statewide protocols for pediatric seizure management exhibit significant variation.
Purpose of the Study:
- To compare statewide prehospital protocols for pediatric seizure management across the United States.
- To identify variations in antiepileptic drug (AED) selection, administration routes, and dosing.
- To analyze differences in the management of febrile seizures within these protocols.
Main Methods:
- Descriptive analysis of statewide EMS protocols for pediatric seizure management in the US.
- Inclusion criteria: availability of statewide protocol or model.
- Comparison of AEDs, routes, dosages, and febrile seizure management strategies.
Main Results:
- 34 of 50 states had usable protocols, all addressing pediatric seizures.
- Significant variability observed in AED recommendations, administration routes (intramuscular, intranasal), and dosing.
- Protocols often included blood glucose measurement (94%) and some addressed febrile seizures (62%).
Conclusions:
- While statewide protocols exist, substantial variability in pediatric seizure management necessitates standardization.
- Areas for improvement include AED dose optimization, prioritizing blood glucose checks, and enhancing intranasal/intramuscular medication guidance.
- Further research should focus on optimizing prehospital pediatric seizure care through evidence-based protocol refinement.
Objective:
The objective of this study was to compare statewide prehospital protocols for the management of pediatric seizures.
Methods:
We performed a descriptive analysis comparing statewide protocols for emergency medical services management of pediatric seizures within the United States, excluding states for which no statewide protocol/model was available. We compared antiepileptic drugs (AEDs), routes and doses of administration, and differences in febrile seizure management.
Results:
Of 50 states, 34 had either statewide protocols or models and were included. All had a protocol for the management of seizures and provided specific recommendations for the management of pediatric seizures. Twelve states (35%) preferentially recommended midazolam over other benzodiazepines. Thirty-two (94%) of 34 allowed for use of midazolam, with variable use of other AEDs. All allowed for use of intramuscular AED. Twenty-six (77%) allowed for intranasal AED. Nine (27%) allowed emergency medical services to administer a patient's own abortive AED, and 6 (18%) allowed for use of a patient's vagal nerve stimulator, when present. There was a wide variability with respect to dosing ranges for medications. Thirty-two (94%) of 34 included blood glucose measurement within the protocol. Twenty-one protocols (62%) provided recommendations for febrile seizures, including recommending active/passive cooling (8/34, 24%) and antipyretic administration (9/34, 26%).
Conclusions:
All statewide protocols carried specific guidelines for the prehospital management of pediatric seizures; however, there was wide variability with respect to specific AEDs, routes of administration, and drug dosages. In addition to broader availability of statewide guidance, areas of potential protocol improvement and research include AED dose optimization, reprioritization of blood glucose, and greater emphasis on intranasal or intramuscular medication dosing.
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Seizures: Classification
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
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