Mechanochemical Synthesis of Functionalized Quinolines by Iodine Mediated Oxidative Annulation
Atreyee Halder1, Debabrata Maiti1, Suman De Sarkar1
1Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, 741246, West Bengal, India.
Abstract:
An iodine-mediated environmentally benign synthesis of multi-substituted quinoline derivatives is developed using a solvent-free mechanochemical process. Appropriately designed and easily accessible protecting group-free aniline derivatives were used for the oxidative annulation reaction, and a series of quinoline derivatives with variable functionalities were synthesized up to 89 % isolated yield. Importantly, the activator iodine remains in the quinoline molecule and promotes further functionalizations. The present methodology is beneficial with regard to operational simplicity and mild reaction conditions.
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