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Related Concept Videos

Methods of Nuclear Reprogramming01:24

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Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
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Introduction to Nuclear Reprogramming01:14

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Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Engineering Biomaterials with Micro/Nanotechnologies for Cell Reprogramming.

Jun Fang1,2, Yuan-Yu Hsueh1,3, Jennifer Soto1,2

  • 1Department of Bioengineering , University of California, Los Angeles , Los Angeles , California 90095 , United States.

ACS Nano
|February 4, 2020
PubMed
Summary
This summary is machine-generated.

Cell reprogramming, a key biotechnology, engineers cell fate using advanced biomaterials and micro/nanotechnologies. These innovations improve reprogramming efficiency for applications in regenerative medicine and drug discovery.

Keywords:
biochemical cuesbiomaterialsbiophysical cuescell reprogrammingdrug deliverynanotechnologythree-dimensional nichestissue engineering

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Area of Science:

  • Biotechnology and Regenerative Medicine

Background:

  • Cell reprogramming is a transformative technology for modifying cell fate and function.
  • Applications include regenerative medicine, disease modeling, and drug discovery.
  • Biomaterials and micro/nanotechnologies are crucial for enhancing reprogramming.

Purpose of the Study:

  • To review state-of-the-art cell reprogramming technologies.
  • To highlight advancements in biomaterial engineering for improved reprogramming.
  • To discuss future challenges and clinical translation.

Main Methods:

  • Review of current literature on cell reprogramming techniques.
  • Analysis of biomaterial and micro/nanotechnology integration.
  • Exploration of delivery strategies and control of biophysical/biochemical cues.

Main Results:

  • Biomaterial and micro/nanotechnology integration significantly enhances reprogramming efficiency and quality.
  • Novel delivery strategies and cue control optimize *in vitro* and *in vivo* reprogramming.
  • Recent breakthroughs demonstrate improved control over cell fate engineering.

Conclusions:

  • Cell reprogramming holds immense potential for therapeutic applications.
  • Continued innovation in biomaterials and nanotechnology is vital for clinical translation.
  • Addressing future challenges will unlock the full potential of reprogramming technologies.