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Updated: Dec 29, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Environmentally Benign Strategy for Arylation of Nitronyl Nitroxide Using a Non-Transition Metal Nucleophile
Shuichi Suzuki1, Fumiya Nakamura1, Takeshi Naota1
1Department of Chemistry, Graduate School of Engineering Science , Osaka University , 1-3 Machikaneyama , Toyonaka , Osaka 560-8531 , Japan.
Abstract:
We have developed a method for the arylation of nitronyl nitroxide without using its transition metal complex as a nucleophile. Various nitronyl nitroxide-substituted π-electronic compounds can be obtained from the parent nitronyl nitroxide and the corresponding aryl iodides using a combination of zero-valent palladium catalysts and a 2-dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl ligand in the presence of sodium tert-butoxide. The utility of the method has been demonstrated by the direct synthesis of open-shell compounds with giant π-electronic systems, such as 10P.
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