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Many transcription factors interact synergistically with steroid receptors
R Schüle1, M Muller, C Kaltschmidt
1Max-Planck Institut für Biochemie, Martinsried, Federal Republic of Germany.
Science (New York, N.Y.)
|December 9, 1988
Abstract:
Progesterone (PRE) or glucocorticoid receptor (GRE) DNA binding sites are often found clustered with binding sites for other transcription factors. Individual protein binding sites were tested without the influence of adjacent factors by analyzing isolated combinations of several transcription factor binding sites with PREs or GREs. All show strong synergistic effects on steroid induction. The degree of synergism is inversely related to the strength of the GRE. Thus, a steroid responsive unit can be composed of several modules that, if positioned correctly, act synergistically.