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A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue
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A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue

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Exploring the role of extracellular matrix proteins to develop biomarkers of plaque vulnerability and outcome

S Holm Nielsen1,2, L Jonasson3, K Kalogeropoulos2

  • 1From the, Biomarkers and Research, Nordic Bioscience, Herlev, Denmark.

Journal of Internal Medicine
|February 4, 2020
PubMed

Insights

Atherosclerotic plaque vulnerability is influenced by extracellular matrix (ECM) remodelling. ECM biomarkers may predict plaque instability and patient outcomes in cardiovascular disease (CVD).

Area of Science:

  • Cardiovascular Medicine
  • Biomedical Engineering
  • Pathology

Background:

  • Cardiovascular disease (CVD) remains a leading cause of mortality in industrialized nations.
  • Atherosclerosis, a primary contributor to CVD, involves the buildup of lipid-rich plaques in arterial walls.
  • The composition of atherosclerotic plaques dictates their vulnerability to rupture or erosion, impacting disease progression.

Purpose of the Study:

  • To review the role of extracellular matrix (ECM) remodelling in atherosclerotic plaque stability and vulnerability.
  • To explore the potential of ECM biomarkers in predicting plaque vulnerability and clinical outcomes.

Main Methods:

  • Literature review focusing on ECM remodelling in atherosclerosis.
  • Analysis of studies investigating the relationship between ECM composition and plaque phenotype.
  • Examination of research on ECM biomarkers for predicting cardiovascular events.

Main Results:

  • ECM remodelling significantly influences atherosclerotic plaque stability and vulnerability.
  • Specific ECM components and their alterations are associated with higher plaque rupture risk.
  • Emerging ECM biomarkers show promise in predicting adverse cardiovascular outcomes.

Conclusions:

  • ECM remodelling is a critical factor in determining atherosclerotic plaque vulnerability.
  • ECM biomarkers hold potential for improved risk stratification and personalized treatment strategies in CVD.
  • Further research into ECM dynamics can enhance our understanding and management of atherosclerosis.

Keywords:
atherosclerosisbiomarkersextracellular matrixoutcomevulnerable plaque

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