Role of the TRPV Channels in the Endoplasmic Reticulum Calcium Homeostasis
Aurélien Haustrate1,2, Natalia Prevarskaya1,2, V'yacheslav Lehen'kyi1,2
1Laboratory of Cell Physiology, INSERM U1003, Laboratory of Excellence Ion Channels Science and Therapeutics, Department of Biology, Faculty of Science and Technologies, University of Lille, 59650 Villeneuve d'Ascq, France.
Abstract:
It has been widely established that transient receptor potential vanilloid (TRPV) channels play a crucial role in calcium homeostasis in mammalian cells. Modulation of TRPV channels activity can modify their physiological function leading to some diseases and disorders like neurodegeneration, pain, cancer, skin disorders, etc. It should be noted that, despite TRPV channels importance, our knowledge of the TRPV channels functions in cells is mostly limited to their plasma membrane location. However, some TRPV channels were shown to be expressed in the endoplasmic reticulum where their modulation by activators and/or inhibitors was demonstrated to be crucial for intracellular signaling. In this review, we have intended to summarize the poorly studied roles and functions of these channels in the endoplasmic reticulum.
Insights
Transient Receptor Potential Vanilloid (TRPV) channels are vital for calcium balance. This review explores their understudied roles within the endoplasmic reticulum, crucial for intracellular signaling.
Area of Science:
- Cell Biology
- Molecular Physiology
- Calcium Signaling
Background:
- Transient Receptor Potential Vanilloid (TRPV) channels are critical for maintaining calcium homeostasis in mammalian cells.
- Dysregulation of TRPV channel activity is linked to various diseases, including neurodegeneration, pain, cancer, and skin disorders.
- Current understanding of TRPV channel function primarily focuses on their plasma membrane localization.
Purpose of the Study:
- To summarize the less-explored functions and roles of TRPV channels within the endoplasmic reticulum.
- To highlight the significance of endoplasmic reticulum-localized TRPV channels in intracellular signaling pathways.
Main Methods:
- Literature review of existing studies on TRPV channel expression and function.
- Analysis of research focusing on TRPV channels in intracellular compartments, particularly the endoplasmic reticulum.
- Synthesis of findings related to the modulation of endoplasmic reticulum TRPV channels by activators and inhibitors.
Main Results:
- Evidence suggests that certain TRPV channels are expressed in the endoplasmic reticulum.
- Modulation of these endoplasmic reticulum TRPV channels impacts intracellular signaling.
- The precise roles of ER-localized TRPV channels remain largely uncharacterized.
Conclusions:
- Endoplasmic reticulum TRPV channels represent a significant, understudied area in cellular physiology.
- Further research into ER TRPV channel function is essential for understanding cellular signaling and disease pathogenesis.
- Targeting ER TRPV channels may offer novel therapeutic strategies for diseases associated with calcium dysregulation.
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