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Persistent Asthma Is Associated With Increased Risk for Incident Atrial Fibrillation in the MESA
Matthew C Tattersall1, Alison S Dasiewicz1,2, Robyn L McClelland2
1Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison (M.C.T., A.D.G., M.M.K., M.H.H., J.H.S.).
Circulation. Arrhythmia and Electrophysiology
|February 5, 2020
Summary
Persistent asthma increases the risk of developing atrial fibrillation (AF), even after accounting for inflammation markers. This study highlights a significant link between severe asthma and cardiovascular health.
Area of Science:
- Cardiology
- Pulmonology
- Inflammation Research
Background:
- Asthma and atrial fibrillation (AF) share common inflammatory pathways.
- Persistent asthma, defined by controller medication use, may elevate AF risk.
Purpose of the Study:
- To investigate the association between asthma severity and incident AF.
- To determine if systemic inflammation markers attenuate the asthma-AF relationship.
Main Methods:
- Analysis of the Multi-Ethnic Study of Atherosclerosis (MESA) cohort.
- Prospective follow-up for incident AF in adults with and without asthma.
- Multivariable Cox regression models adjusting for risk factors and inflammation markers.
Main Results:
- Persistent asthma was associated with a significantly higher risk of incident AF (HR, 1.49).
- Inflammation markers (IL-6, TNF-α R1, D-dimer) predicted AF.
- The association between persistent asthma and AF was not attenuated by adjustment for inflammation markers.
Conclusions:
- Persistent asthma is linked to an increased risk of developing atrial fibrillation.
- Inflammatory biomarkers do not fully explain the association between persistent asthma and AF.
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