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Related Concept Videos

The Retinoblastoma Gene01:20

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Related Experiment Video

Updated: Dec 29, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
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Cellular Retinoic-Acid Binding Protein 2 in Solid Tumor.

Xiaoyang Jiao1, Rang Liu2, Jiali Huang2

  • 1Cell biology and genetics department, Shantou University Medical College Shantou, Guangdong, China.

Current Protein & Peptide Science
|February 5, 2020
PubMed
Summary

Cellular Retinoic-Acid Binding Protein 2 (CRABP2) plays a complex role in cancer, affecting tumor growth and spread. Understanding CRABP2's mechanisms is key for developing new cancer biomarkers and therapies.

Keywords:
CRABP2Retinoic-acidproteinsignaling pathwaysolid tumortumor.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • The retinoic acid (RA) signaling pathway is vital for biological processes.
  • Abnormal expression of the RA transporter, Cellular Retinoic-Acid Binding Protein 2 (CRABP2), is observed in various cancers.
  • CRABP2 influences critical tumor behaviors like proliferation, apoptosis, invasion, migration, metastasis, and angiogenesis.

Purpose of the Study:

  • To review the expression, distribution, and mechanisms of CRABP2 in solid tumors.
  • To highlight the complex, dual role of CRABP2 in tumorigenesis (suppressor and promoter).
  • To emphasize the need for further investigation into CRABP2's regulatory mechanisms in specific tumor stages.

Main Methods:

  • Literature review of CRABP2 expression and function in solid tumors.
  • Analysis of CRABP2's involvement in cancer hallmarks.
  • Synthesis of current knowledge on CRABP2's role in tumorigenesis.

Main Results:

  • CRABP2 exhibits abnormal expression across diverse tumor types.
  • CRABP2 significantly impacts multiple tumor cell functions and behaviors.
  • The precise mechanism of CRABP2 in cancer development is complex and requires further elucidation.

Conclusions:

  • Elucidating CRABP2's regulatory mechanisms can establish it as a biomarker for cancer diagnosis and prognosis.
  • Understanding CRABP2 pathways in cancer development is crucial for advancing gene-targeted therapies.
  • Further research into the CRABP2 signaling pathway may enhance understanding of retinoid signaling and aid clinical trials.