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Meta-analysis of C-Reactive Protein and Risk of Angina Pectoris

Ruo-Fei Jia1, Long Li1, Hong Li1

  • 1Department of Cardiovascular, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

The American Journal of Cardiology
|February 5, 2020
PubMed

Insights

Elevated C-reactive protein (CRP) levels are linked to a higher risk of angina pectoris. This meta-analysis confirms CRP as a potential risk factor for major adverse cardiac events in angina patients.

Area of Science:

  • Cardiology
  • Biomarkers
  • Inflammation

Background:

  • Long-standing reports suggest a link between C-reactive protein (CRP) and angina pectoris risk.
  • Previous findings remain controversial, necessitating further investigation.

Purpose of the Study:

  • To conduct a meta-analysis to clarify the association between CRP levels and angina pectoris.
  • To evaluate CRP as a potential risk factor for major adverse cardiac events in angina patients.

Main Methods:

  • A comprehensive literature search was performed across PubMed, EMBASE, Cochrane Library, and Web of Science.
  • Included 10 prospective cohort studies and 11 case-control studies, totaling 18,316 participants.
  • Data were pooled to calculate the mean difference in CRP levels and the odds ratio for adverse events.

Main Results:

  • A pooled mean difference of 4.44 (95% CI 2.71 to 6.17) in CRP levels was observed between angina patients and healthy controls.
  • The combined odds ratio for major adverse cardiac events associated with CRP in angina patients was 1.67 (95% CI 1.23 to 2.26).

Conclusions:

  • Elevated CRP levels are significantly associated with angina pectoris, particularly unstable angina pectoris.
  • CRP is likely a risk factor for major adverse cardiac events in individuals with angina.

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