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Updated: Dec 29, 2025
A Murine Model of Vertical Sleeve Gastrectomy
Published on: December 18, 2017
Effect of sleeve gastrectomy on plasma growth differentiation factor-15 (GDF15) in human
Ponnie Robertlee Dolo1, Libin Yao1, Peng Peng Liu1
1Department of General Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221006, PR China; Institute of Digestive Diseases, Xuzhou Medical University Xuzhou Jiangsu, 221006, PR China.
Background:
Sleeve gastrostomy (SG) induces significant weight loss primarily as a result of increased satiety and reduced food intake. Growth differentiation factor-15 (GDF15) is a satiety hormone which induces a dramatic reduction of food intake and body weight.
Objective:
To assess the effect of sleeve gastrectomy on plasma GDF 15 level and the association with the weight loss and diabetes control after SG.
Method:
We assessed plasma GDF15 level in 21 patients (15 with obesity and 6 with obesity and diabetes) before and then at 1, 3 and 12 months after SG.
Results:
GDF15 was significantly increased at 1 month after SG compared to before surgery level (301.9 ± 135.2 pg/ml vs 215.1 ± 119.9 pg/ml, respectively p<0.05) and increased even further at 3 months (338.86 ± 131.14 pg/ml, p<0.01) and remain elevated at 12 months (329.39 ± 152.1 pg/ml p<0.05) after SG. At 3 months after surgery, the increased GDF15 level was correlated with the magnitude of BMI loss (r2 = 0.204, p<0.05).
Conclusion:
SG induces a significant increase in GDF15 level which is correlated with the magnitude of BMI loss.
