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Pharmacogenomics: An evolving clinical tool for precision medicine
Jennifer K Hockings1, Amy L Pasternak2, Angelika L Erwin3
1Department of Pharmacy, Cleveland Clinic; Genomic Medicine Institute, Lerner Research Institute, and Center for Personalized Genetic Healthcare, Cleveland Clinic Community Care hockinc@ccf.org.
Cleveland Clinic Journal of Medicine
|February 5, 2020
Summary
Pharmacogenomics, the study of genetic influences on drug response, helps optimize medication. Integrating this science can improve treatment, reduce adverse drug reactions, and lower healthcare costs.
Area of Science:
- Genomic Medicine
- Clinical Pharmacology
Background:
- Pharmacogenomics studies how individual genetic makeup affects drug efficacy and toxicity.
- Genetic variations can significantly increase the risk of severe adverse drug events.
Purpose of the Study:
- To highlight the clinical utility of pharmacogenomics in optimizing drug therapy.
- To underscore the potential benefits of integrating pharmacogenomics into routine clinical practice.
Main Methods:
- Review of existing literature on pharmacogenomics and clinical drug response.
- Analysis of the impact of genetic variants on drug-induced adverse events.
Main Results:
- Pharmacogenomics provides a framework for personalized drug selection and dosing.
- Identified genetic variants are linked to increased risk of severe, life-threatening drug reactions.
Conclusions:
- Integrating pharmacogenomics into clinical practice can enhance treatment outcomes.
- Personalized medicine approaches using pharmacogenomics reduce drug-related morbidity and mortality.
- Pharmacogenomic integration offers potential cost-effectiveness in healthcare.
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